Cross-reactive T cell recognition between ‘common cold’ and CoV-2

Covid-19 discussion, bring your own statistics
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Beaker
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Cross-reactive T cell recognition between ‘common cold’ and CoV-2

Post by Beaker » Fri May 15, 2020 7:51 am

Interesting suggestions for immunity here. Not my field, but it looks possibly optimistic.
Importantly, we detected SARS-CoV-2−reactive CD4+ T cells in ∼40-60% of unexposed individuals, suggesting cross-reactive T cell recognition between circulating ‘common cold’ coronaviruses and SARS-CoV-2
https://www.cell.com/cell/fulltext/S00 ... ctitle0015

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Martin Y
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Re: Cross-reactive T cell recognition between ‘common cold’ and CoV-2

Post by Martin Y » Fri May 15, 2020 9:47 am

To help those of us below minimum understanding; is the implication that roughly half of people might have some small advantage in immune response to Covid19 due to previous common cold exposure?

Beaker
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Re: Cross-reactive T cell recognition between ‘common cold’ and CoV-2

Post by Beaker » Fri May 15, 2020 10:26 am

Yes, that’s how it was suggested to me by someone who knows more than I do about this field.

AMS
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Re: Cross-reactive T cell recognition between ‘common cold’ and CoV-2

Post by AMS » Fri May 15, 2020 11:45 am

Interesting to know if this explains the discrepancy between asymptotic/mild v severe cases. If I remember right, T-cell responses get weaker in old age too.

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Martin Y
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Re: Cross-reactive T cell recognition between ‘common cold’ and CoV-2

Post by Martin Y » Fri May 15, 2020 12:19 pm

Well in that case I'm now glad I had a stinking cold just as all this was kicking off. :)

raven
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Re: Cross-reactive T cell recognition between ‘common cold’ and CoV-2

Post by raven » Fri May 15, 2020 4:17 pm

I seem to remember something on the radio early on in all this, about similarity to cold viruses circulating back in the 80s that might confer some partial immunity. No idea if that came to anything.

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Gfamily
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Re: Cross-reactive T cell recognition between ‘common cold’ and CoV-2

Post by Gfamily » Fri May 15, 2020 5:14 pm

Is this the first time that an xkcd might have been refuted effectively on the day after it was published?

https://m.xkcd.com/2306/
common_cold.png
common_cold.png (80.35 KiB) Viewed 99 times
My avatar was a scientific result that was later found to be 'mistaken' - I rarely claim to be 100% correct

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