Long Covid

Covid-19 discussion, bring your own statistics
raven
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Re: Long Covid

Post by raven » Tue Mar 23, 2021 6:01 pm

That's very interesting. Although presumably some case of long covid do spontaneously resolve, so you'd have to take that into account.

From that article:
In a post on the blog Elemental, Iwasaki proposed three reasons vaccines might improve people’s symptoms: T cells, boosted by the vaccine, could eliminate a viral reservoir; a heightened immune response could clear any lingering virus fragments; or the vaccine may “divert autoimmune cells,” if long-lasting symptoms are the result of an inappropriate autoimmune response.
That last idea is very appealing. Whatever causes the mild fatigue/fibromyalgia-like symptoms I get, it always seems to stop when I get sick. I have wondered if that was down to giving the immune system a fresh target but also if it might just be diverting my attention to the more acute symptoms. It's very tempting to believe the former, but I suspect it's more likely to be the latter.

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Woodchopper
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Re: Long Covid

Post by Woodchopper » Sat Mar 27, 2021 7:17 pm

Persistent neurologic symptoms and cognitive dysfunction in non‐hospitalized Covid‐19 “long haulers”

Mean age was 43.2±11.3 years, 70% were female and 48% were evaluated in televisits. The most frequent comorbidities were depression/anxiety (42%) and autoimmune disease (16%). The main neurologic manifestations were: “brain fog” (81%), headache (68%), numbness/tingling (60%), dysgeusia (59%), anosmia (55%), myalgias (55%), with only anosmia being more frequent in SARS‐CoV‐2+ than SARS‐CoV‐2‐ patients (37/50 [74%] vs (18/50 [36%]; p <0.001). Moreover, 85% also experienced fatigue. There was no correlation between time from disease onset and subjective impression of recovery. Both groups exhibited impaired quality of life in cognitive and fatigue domains. SARS‐CoV‐2+ patients performed worse in attention and working memory cognitive tasks compared to a demographic‐matched US population (T‐score 41.5 [37, 48.25] and 43 [37.5, 48.75], respectively; both p<0.01).
https://onlinelibrary.wiley.com/doi/10.1002/acn3.51350

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Woodchopper
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Re: Long Covid

Post by Woodchopper » Wed Apr 14, 2021 4:38 am


Background. In a proportion of patients recovered from the acute COVID-19 phase, a variable range of symptoms has been observed to persist for at least 6-months. Objectives. The main aim of this study was to evaluate the prevalence of COVID-related symptoms 12-months after the onset of mild-to-moderate disease. Methods Prospective study based on structured questionnaires and additional outcomes.

Results 304/354 patients completing the survey at baseline also completed the follow-up interview (85.9%; median [range] age, 47 [18-76] years; 185 [60.9%] women). Persistence of at least one symptom at 12-months follow-up was reported by 161 patients (53.0%). The most commonly reported symptom of long COVID was felt tired (n=83, 27.3%), followed by smell or taste impairment (n=67, 22.0%), shortness of breath (n=39, 12.8%) and muscle pain (n=28, 9.2%). Being females (OR=1.64; 95% CI: 1.00-2.70), aged between 40-54 (OR=1.92; 95% CI: 1.07-3.44), having a BMI[ge]25 (OR=1.67; 95% CI: 1.00-2.78), and experiencing more symptoms during the acute phase of the disease (OR=8.71 for [ge]8 symptoms; 95% CI: 2.73-27.76) were associated with long COVID. Persistence of symptoms showed a significant impact on quality of life (p[lt];0.0001) and depression scale scores (p=0.0102).

Conclusion More than half of patients with previous mild-to-moderate symptomatic COVID-19 complained the persistence of at least one symptom 12-months after the onset of the illness.
https://www.medrxiv.org/content/10.1101 ... 21255343v1

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Woodchopper
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Re: Long Covid

Post by Woodchopper » Wed Apr 14, 2021 2:40 pm

Scientists haven’t figured out long Covid. Here are 5 of their best hypotheses.
From disturbing the gut microbiome to lingering in the brain, there are many ways the coronavirus might cause lasting symptoms.
https://www.vox.com/22369734/long-hauler-covid-vaccine

Herainestold
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Re: Long Covid

Post by Herainestold » Wed Apr 14, 2021 5:52 pm

What are the numbers for vaccinated people getting Long Covid? Anybody know? I havent seen anything besides anecdote.

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Martin_B
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Re: Long Covid

Post by Martin_B » Thu Apr 15, 2021 3:30 am

Herainestold wrote:
Wed Apr 14, 2021 5:52 pm
What are the numbers for vaccinated people getting Long Covid? Anybody know? I havent seen anything besides anecdote.
At this stage I don't think there would be any numbers other than anecdote; we're still pretty early in the vaccination programme for Long Covid to be showing up.

Or did you mean how do the vaccines affect people with Long Covid already identified? I thought that the anecdata for that showed some improvement in symptoms, but I've not seen any specific studies into it.
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Herainestold
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Re: Long Covid

Post by Herainestold » Thu Apr 15, 2021 2:31 pm

Martin_B wrote:
Thu Apr 15, 2021 3:30 am
Herainestold wrote:
Wed Apr 14, 2021 5:52 pm
What are the numbers for vaccinated people getting Long Covid? Anybody know? I havent seen anything besides anecdote.
At this stage I don't think there would be any numbers other than anecdote; we're still pretty early in the vaccination programme for Long Covid to be showing up.

Or did you mean how do the vaccines affect people with Long Covid already identified? I thought that the anecdata for that showed some improvement in symptoms, but I've not seen any specific studies into it.
There's been a lot in the media lately about vaccinated people with covid. Not really surprising considering vaccination is only 80-90% effective.
Just wondering how that translates into long covid. More or less likely? Can you experience long covid without the severe symptoms of acute covid?
could there be a bunch of vaccinated long covid sufferers out there that have not been identified?

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Woodchopper
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Re: Long Covid

Post by Woodchopper » Mon May 10, 2021 8:45 pm


At least 16,000 people in Sweden have had their health damaged long-term by a Covid-19 infection, reports Swedish Radio News.

Tomas Lindén at the Board of Health and Welfare says this shows we will live with consequences of the pandemic for a long time.

The figure does not differentiate between those who are suffering from serious symptoms such as trouble breathing and chest pains, and those with mild symptoms.
https://sverigesradio.se/artikel/at-lea ... term-covid

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