Long Covid

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shpalman
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Re: Long Covid

Post by shpalman » Fri Jan 07, 2022 9:45 am

Also be careful not to multiply the most severe symptoms of long covid by the percentage of people who suffered any degree of long-term symptoms post-covid.
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Re: Long Covid

Post by Bird on a Fire » Fri Jan 07, 2022 11:29 am

Yep, I've been f.cking knackered since about March last year, but didn't get covid till I came to England for Christmas.
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Re: Long Covid

Post by Martin_B » Sat Jan 08, 2022 2:09 am

Bird on a Fire wrote:
Fri Jan 07, 2022 11:29 am
Yep, I've been f.cking knackered since about March last year, ...
I've had that; I think it's called getting old, mate.
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Re: Long Covid

Post by Woodchopper » Sat Jan 08, 2022 11:18 pm

Increased risk of diabetes in children after Covid infection: https://www.cdc.gov/mmwr/volumes/71/wr/mm7102e2.htm

Cause unknown.

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Re: Long Covid

Post by raven » Mon Jan 10, 2022 9:31 pm

Pancreatic tissue can have ACE-2 receptors, I think, so there's a possible plausible mechanism for damage.

I meant to post this link here: Could microclots help explain the mystery of long Covid?
Seems like a potential explanation for some of the after effects of Covid. Not sure that it'd apply to ME/CFS as they suggest though.

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Re: Long Covid

Post by Woodchopper » Thu Jan 13, 2022 9:06 pm


Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection
https://www.nature.com/articles/s41590-021-01113-x

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Re: Long Covid

Post by FlammableFlower » Fri Jan 14, 2022 3:41 pm


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Woodchopper
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Re: Long Covid

Post by Woodchopper » Tue Jan 25, 2022 8:40 pm


Cerebrospinal Fluid Offers Clues to Post-COVID ‘Brain Fog’
Over-Stimulated Immune System May Be Impetus to Cognitive Symptoms, UCSF-Led Study Shows
https://www.ucsf.edu/news/2022/01/42215 ... -brain-fog

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Woodchopper
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Re: Long Covid

Post by Woodchopper » Tue Feb 08, 2022 8:07 am


The cardiovascular complications of acute coronavirus disease 2019 (COVID-19) are well described, but the post-acute cardiovascular manifestations of COVID-19 have not yet been comprehensively characterized. Here we used national healthcare databases from the US Department of Veterans Affairs to build a cohort of 153,760 individuals with COVID-19, as well as two sets of control cohorts with 5,637,647 (contemporary controls) and 5,859,411 (historical controls) individuals, to estimate risks and 1-year burdens of a set of pre-specified incident cardiovascular outcomes. We show that, beyond the first 30 d after infection, individuals with COVID-19 are at increased risk of incident cardiovascular disease spanning several categories, including cerebrovascular disorders, dysrhythmias, ischemic and non-ischemic heart disease, pericarditis, myocarditis, heart failure and thromboembolic disease. These risks and burdens were evident even among individuals who were not hospitalized during the acute phase of the infection and increased in a graded fashion according to the care setting during the acute phase (non-hospitalized, hospitalized and admitted to intensive care). Our results provide evidence that the risk and 1-year burden of cardiovascular disease in survivors of acute COVID-19 are substantial. Care pathways of those surviving the acute episode of COVID-19 should include attention to cardiovascular health and disease.
https://www.nature.com/articles/s41591-022-01689-3

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Re: Long Covid

Post by Herainestold » Sat Feb 26, 2022 5:28 am

Are Putin's actions due to Long Covid?
Although it's not clear if he's had the virus, the Sputnik vaccine is not known to be reliable and after isolating in September after members of his inner circle tested positive he disappeared from view for a long period in October.

The US thinktank The Council For Foreign relations has speculated that, after behaviour and statements that are 'off' and 'not right,' he is suffering brain fog induced by Long Covid.

What's more, the isolation caused by the pandemic itself could have left the 69-year-old even further detached from reality, with one neuropsychologist claiming the 'progressive isolation' could have led to hubris syndrome, which 'diminished his ability to weigh up risk'.

Speaking to FEMAIL, Clinical Director at Medicine Direct. Hussain Abdeh explained how a person's mental state could be uprooted by the virus.

He explained: 'Research early on into the pandemic also found that a small number of people who tested positive for COVID-19 experienced sudden behavioural changes including delirium, confusion, and agitation.'
https://www.dailymail.co.uk/femail/arti ... n-mad.html
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Re: Long Covid

Post by WFJ » Sat Feb 26, 2022 6:16 pm

Herainestold wrote:
Sat Feb 26, 2022 5:28 am
Are Putin's actions due to Long Covid?
Are Putin's actions due to tertiary syphilis?

This question makes just as much sense.

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Re: Long Covid

Post by Herainestold » Sat Feb 26, 2022 7:47 pm

WFJ wrote:
Sat Feb 26, 2022 6:16 pm
Herainestold wrote:
Sat Feb 26, 2022 5:28 am
Are Putin's actions due to Long Covid?
Are Putin's actions due to tertiary syphilis?

This question makes just as much sense.
It could be both. Long Covid and syphilis.
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Re: Long Covid

Post by bob sterman » Sat Feb 26, 2022 8:11 pm

Herainestold wrote:
Sat Feb 26, 2022 7:47 pm
WFJ wrote:
Sat Feb 26, 2022 6:16 pm
Herainestold wrote:
Sat Feb 26, 2022 5:28 am
Are Putin's actions due to Long Covid?
Are Putin's actions due to tertiary syphilis?

This question makes just as much sense.
It could be both. Long Covid and syphilis.
I think for Herainestold everything is due to COVID - even COVID is probably due to Long Covid. Brain fog in laboratory workers earlier infected with a version of the coronovirus, led them to get confused and mix up their flask of tea with one containing SARS-CoV-2, when they popped out for lunch at the wet market.

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Re: Long Covid

Post by Woodchopper » Fri Mar 04, 2022 2:53 am

The COVID Heart—One Year After SARS-CoV-2 Infection, Patients Have an Array of Increased Cardiovascular Risks
https://jamanetwork.com/journals/jama/f ... le/2789793

Summary of research posted earlier.

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Re: Long Covid

Post by raven » Sun Mar 06, 2022 10:57 pm

That's both concerning and not entirely unexpected for a virus that messes with the cardiovascular system.

I'd like to think vaccines go some way to protect against these longer term problems that are showing up, but I don't know if there's any evidence of that yet.

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Re: Long Covid

Post by Woodchopper » Fri Jun 17, 2022 8:36 am

Risk of long COVID associated with delta versus omicron variants of SARS-CoV-2
https://www.thelancet.com/journals/lanc ... 2/fulltext

tl;dr Omicron has a reduced risk of long covid compared to Delta.

Not surprising as Omicron also has lower risks of hospitalization and death. But still, good to see it in a study.

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Re: Long Covid

Post by Chris Preston » Mon Apr 17, 2023 5:19 am

There is a recent report out of Queensland Health (press release https://www.eurekalert.org/news-releases/986131) showing that long COVID impact is similar to influenza post-viral syndrome - provided you are vaccinated.

Most of the news reports I am seeing are leaving off that last part.

The impact of long COVID is much higher, because many more people catch COVID-19 than do influenza.
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Re: Long Covid

Post by Herainestold » Sat Apr 22, 2023 3:34 pm

This virus has mutated and changed to the point that Long Covid is worse than the actual infection and it is the major health consequence of Covid-19.

https://twitter.com/edyong209/status/16 ... 0661235746
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Re: Long Covid

Post by Millennie Al » Sun Apr 23, 2023 12:05 am

Herainestold wrote:
Sat Apr 22, 2023 3:34 pm
This virus has mutated and changed to the point that Long Covid is worse than the actual infection and it is the major health consequence of Covid-19.
Is that severity of long Covid caused by the early variants or the recent ones? Because it it's the former, a fairer way to express the idea would be to say that the virus has changed so that now it is so mild that long Covid is worse.

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Re: Long Covid

Post by Herainestold » Sun Apr 23, 2023 12:57 am

Millennie Al wrote:
Sun Apr 23, 2023 12:05 am
Herainestold wrote:
Sat Apr 22, 2023 3:34 pm
This virus has mutated and changed to the point that Long Covid is worse than the actual infection and it is the major health consequence of Covid-19.
Is that severity of long Covid caused by the early variants or the recent ones? Because it it's the former, a fairer way to express the idea would be to say that the virus has changed so that now it is so mild that long Covid is worse.
That is only half the story, the newer variants are worse for Long Covid.
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Re: Long Covid

Post by shpalman » Sun Apr 23, 2023 7:17 am

Herainestold wrote:
Sun Apr 23, 2023 12:57 am
Millennie Al wrote:
Sun Apr 23, 2023 12:05 am
Herainestold wrote:
Sat Apr 22, 2023 3:34 pm
This virus has mutated and changed to the point that Long Covid is worse than the actual infection and it is the major health consequence of Covid-19.
Is that severity of long Covid caused by the early variants or the recent ones? Because it it's the former, a fairer way to express the idea would be to say that the virus has changed so that now it is so mild that long Covid is worse.
That is only half the story, the newer variants are worse for Long Covid.
If they're that new then nobody has had that covid long enough for it to be long covid.
having that swing is a necessary but not sufficient condition for it meaning a thing
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Re: Long Covid

Post by Herainestold » Tue Apr 25, 2023 4:22 pm

Did anybody read the Ed Yong article in the Atlantic, referenced up thread.
His thesis is that society wants Covid to be over, but Long Covid is a devastating chronic illness affecting many people, that the medical establishment refuses to take seriously. So Covid isn't over, not by a long shot
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Re: Long Covid

Post by shpalman » Tue Apr 25, 2023 5:16 pm

Herainestold wrote:
Tue Apr 25, 2023 4:22 pm
Did anybody read the Ed Yong article in the Atlantic, referenced up thread.
His thesis is that society wants Covid to be over, but Long Covid is a devastating chronic illness affecting many people, that the medical establishment refuses to take seriously. So Covid isn't over, not by a long shot
What it doesn't say is that
Herainestold wrote:
Sat Apr 22, 2023 3:34 pm
This virus has mutated and changed to the point that Long Covid is worse than the actual infection and it is the major health consequence of Covid-19.

https://twitter.com/edyong209/status/16 ... 0661235746
but it argues that while the medical establishment doesn't yet take it seriously enough, things are better than they were.
What was once outright denial has morphed into a subtler dismissal.
The most recent data from the U.S. and the U.K. show that the total number of long-haulers has decreased over the past six months, which certainly suggests that people recover in appreciable numbers. But there’s a catch: In the U.K., the number of people who have been sick for more than a year, or who are severely limited by their illness, has gone up.
So that would relate to what the virus was doing over a year ago, which we can hardly do anything about now.
Contrary to popular belief, researchers have learned a huge amount about the biochemical basis of long COVID, and have identified several potential biomarkers for the disease.
So, those researchers aren't refusing to take it seriously. But, what popular belief?
Long COVID can also seem bafflingly invisible when people look at it with the wrong tools. For example, a 2022 study by National Institutes of Health researchers compared 104 long-haulers with 85 short-term COVID patients and 120 healthy people and found no differences in measures of heart or lung capacities, cognitive tests, or levels of common biomarkers—bloodstream chemicals that might indicate health problems.
Those beliefs from earlier on in the same article?
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Re: Long Covid

Post by IvanV » Wed Apr 26, 2023 8:36 am

shpalman wrote:
Tue Apr 25, 2023 5:16 pm
What it doesn't say is that
Herainestold wrote:
Sat Apr 22, 2023 3:34 pm
This virus has mutated and changed to the point that Long Covid is worse than the actual infection and it is the major health consequence of Covid-19.

https://twitter.com/edyong209/status/16 ... 0661235746
A good reason for it not to say it is that for many people, like me, long Covid is worse than the actual infection even for original Covid V1.0, which they might have caught, like me, even before the first lockdown. For many people, original Covid was often either asymptomatic, or a mild indisposition, whereas the long Covid is actually a serious blight on your health.

The only reason I knew I'd had Covid V1.0 before lockdown, which presented to me as just feeling a bit under the weather for two or three days, was because of the long Covid that followed it.

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Re: Long Covid

Post by Woodchopper » Thu Jan 04, 2024 4:32 pm

Some good news

A growing consensus is emerging that receiving multiple doses of the COVID vaccine before an initial infection can dramatically reduce the risk of long-term symptoms. Although the studies disagree on the exact amount of protection, they show a clear trend: the more shots in your arm before your first bout with COVID, the less likely you are to get long COVID. One meta-analysis of 24 studies published in October, for example, found that people who’d had three doses of the COVID vaccine were 68.7 percent less likely to develop long COVID compared with those who were unvaccinated. “This is really impressive,” says Alexandre Marra, a medical researcher at the Albert Einstein Israelite Hospital in Brazil and the lead author of the study. “Booster doses make a difference in long COVID.”

[…]

A study published in November in the BMJ found that a single COVID vaccine dose reduced the risk of long COVID by 21 percent, two doses reduced it by 59 percent and three or more doses reduced it by 73 percent. Vaccine effectiveness clearly climbed with each successive dose.

[…]

That lines up with the findings of several new studies, which similarly show this ladderlike benefit. Marra’s October 2023 meta-analysis found that two doses reduced long COVID likelihood by 36.9 percent and three doses reduced it by 68.7 percent. And in a study published last year in the Journal of the American Medical Association, other researchers found that the prevalence of long COVID in health care workers dropped from 41.8 percent in unvaccinated participants to 30 percent in those with a single dose, 17.4 percent with two doses and 16 percent with three doses.

[…]

Marra’s recent meta-analysis, for example, showed that the prevalence of long COVID in the early years of the pandemic was consistently above 20 percent. Today rates of long COVID have dropped, likely thanks to increased immunity, milder variants and improved treatment. Yet there is still a sharp divide between unvaccinated and vaccinated people. The prevalence of long COVID is currently 11 percent among those who are unvaccinated and 5 percent among those who have had two or more doses of the vaccine.
https://www.scientificamerican.com/arti ... ovid-risk/

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