A lab in Italy reported a cluster of the U.K. coronavirus variant. But that wasn’t enough to stop the spread.
The virus hunter saw the apparent pattern come into view over several hours in late December, as he studied genetic sequences from positive coronavirus tests in his region. He found four cases involving the new, highly infectious British variant, in the same hilltop town.
“A cluster,” said Alessio Lorusso, the virologist.
His findings were a rare, initial insight into the mutated forms of the virus reaching new parts of the world. Most countries, including the United States and across Europe, do not perform enough genomic surveillance to adequately track the virus’s changes — to the alarm of disease control agencies, which warn that governments could be blind to dangerous mutations.
But the scenario in Italy’s mountainous center shows how even when a worrisome variant is detected early, governments can miss the narrow window to mount a rapid response and limit the spread. Containment measures come too late, in the wait for more substantial evidence. And the virus races ahead.
Lorusso’s director quickly notified the affected region of the four cases. But it took more than two weeks for any official confirmation to reach the town of Guardiagrele and its population of 9,000. During that time, overall coronavirus cases there tripled, from 35 on Dec. 28 to more than 100 by mid-January. Of those, 29 have been confirmed to involve the British variant
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No targeted restrictions have been imposed on Guardiagrele or the surrounding region of Abruzzo, though there is a plan to soon perform widespread testing.
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“If you don’t act now, in two months, in all of Europe, we’ll have the British variant taking the place of the current ones,” said Walter Ricciardi, a World Health Organization adviser to Italy’s Health Ministry.
He said that if a highly transmissible variant is detected in a particular place, it is important to act quickly, with widespread testing and restrictions on movement.
“You have to immediately lock down the area,” Ricciardi said.
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Italy reported its first detected case involving the British variant on Dec. 20, in a traveler who had arrived from Britain. The government in Rome stopped flights from the United Kingdom the same day.
But even by then, the variant was apparently already circulating in Italy.
Lorusso spotted the initial four cases from Guardiagrele — three within one family — on Dec. 26, and by Dec. 30, according to a document, the lab had informed regional government officials.
Regional officials, in turn, said they needed national government confirmation of the lab results. Into mid-January, the region was insisting there was still no “definitive proof” of a variant that might be spreading differently.
“The region never said to me, ‘Dear mayor, there is a cluster in your town of the most infectious variant, so you’d better put a stop to everything,’ ” said Guardiagrele’s mayor, Donatello Di Prinzio. “Had that been the case, I would have taken all the required actions.”
Instead, after the end of a national holiday lockdown, all of Abruzzo — including his town — landed back in the lightest tier of Italian restrictions, with shops and hair salons open, and restaurants allowed to offered dine-in service until 6 p.m.
Meanwhile, coronavirus infections in the town were rising rapidly, reaching a point far exceeding anything from earlier waves. A local media report pointed to the variant, and there was speculation about it on Facebook. But without official word, the mayor said he didn’t want to be alarmist.
“I only talk when there is data on my hand and official information,” he said.
While he waited, Di Prinzio asked the region to send civil protection officers, who could supplement a depleted local police unit and help enforce basic distancing measures.
Then, on Tuesday, he was invited to a video conference with a provincial official and mayors from seven other towns that were seeing significant case increases. The authorities agreed to launch a mass-testing campaign in those towns, starting in Guardiagrele. It would kick off Jan. 23 — more than three weeks after Lorusso’s initial findings.
One of the provincial officials involved with the health response, Giuseppe Torzi, said “measures need to be stricter” in places with the variant, but the crux of the response would be the same: try to isolate the positive cases and reduce contacts.
“I could list situations where there’s no English variant and yet there’s been a monstrous increase,” Torzi said. “So it’s not as if the other virus is some joke.”
On Friday, Guardiagrele received definitive word of the variant’s arrival, but not because of a national confirmation. Instead, Lorusso’s lab notified the region, as well as a provincial health director, of updated, more extensive findings. Torzi called the mayor, feeling this time no further research was needed.
The province of Chieti, one portion of Abruzzo, had 51 cases of the variant.
Twenty-nine of those were in Guardiagrele.
That news coincided with a national government order that a large part of the country, including the Abruzzo region, would on the basis of infection rates be classified in the middle tier of coronavirus restrictions, which includes the closure of restaurants for in-person dining. Nonessential travel between regions will be banned through mid-February. But there has been no indication that Guardiagrele would be sealed off, as has happened in numerous hot spot Italian towns throughout the past year.
Speaking to The Washington Post by phone on Friday, Di Prinzio said he would redouble his request for residents to wear masks and keep their distance. He’d already closed a market. Nothing else would change. Even if he wanted to impose a lockdown, he said there was little point; other towns might well have the same problem, and it would have to be a coordinated effort.
Another lab doing genomic sequencing, at the University of Chieti, said it had traced a case in one town, San Giovanni Teatino, back to Guardiagrele, carried by a woman who works there.
“For such reason,” the university wrote to the region, “it is possible to hypothesize that in these cases we are witnessing a progressive expansion of such a variant across the territory.”
