Vaccine rollout in Nauru

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Brightonian
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Vaccine rollout in Nauru

Post by Brightonian » Tue May 18, 2021 4:56 pm

...is complete.

Or rather, everyone's had their first jab. Annoys me when people imply having a first jab means you're vaccinated.

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Re: Vaccine rollout in Nauru

Post by shpalman » Tue May 18, 2021 5:02 pm

Brightonian wrote:
Tue May 18, 2021 4:56 pm
...is complete.

Or rather, everyone's had their first jab. Annoys me when people imply having a first jab means you're vaccinated.
You're probably well protected 2—3 weeks after the first jab.
having that swing is a necessary but not sufficient condition for it meaning a thing
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Herainestold
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Re: Vaccine rollout in Nauru

Post by Herainestold » Tue May 18, 2021 5:11 pm

Brightonian wrote:
Tue May 18, 2021 4:56 pm
...is complete.

Or rather, everyone's had their first jab. Annoys me when people imply having a first jab means you're vaccinated.
Data from Israel indicates you are more susceptible after the first dose for up to a week. After 2 weeks you should take precautions as if you are un vaccinated.
Masking forever
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Re: Vaccine rollout in Nauru

Post by headshot » Tue May 18, 2021 5:54 pm

Herainestold wrote:
Tue May 18, 2021 5:11 pm
Brightonian wrote:
Tue May 18, 2021 4:56 pm
...is complete.

Or rather, everyone's had their first jab. Annoys me when people imply having a first jab means you're vaccinated.
Data from Israel indicates you are more susceptible after the first dose for up to a week. After 2 weeks you should take precautions as if you are un vaccinated.
Citation please.

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Re: Vaccine rollout in Nauru

Post by jdc » Tue May 18, 2021 7:56 pm

headshot wrote:
Tue May 18, 2021 5:54 pm
Herainestold wrote:
Tue May 18, 2021 5:11 pm
Brightonian wrote:
Tue May 18, 2021 4:56 pm
...is complete.

Or rather, everyone's had their first jab. Annoys me when people imply having a first jab means you're vaccinated.
Data from Israel indicates you are more susceptible after the first dose for up to a week. After 2 weeks you should take precautions as if you are un vaccinated.
Citation please.
I think this may be what H is thinking of: https://www.medrxiv.org/content/10.1101 ... 21250957v1
After initial injection case numbers increased to day 8 before declining to low levels by day 21. Estimated vaccine effectiveness was pretty much 0 at day 14 but then rose to about 90% at day 21 before levelling off. The cause of the initial surge in infection risk is unknown but may be related to people being less cautious about maintaining protective behaviours as soon as they have the injection. What our analysis shows is that a single dose of vaccine is highly protective, although it can take up to 21 days to achieve this.

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Re: Vaccine rollout in Nauru

Post by headshot » Tue May 18, 2021 9:07 pm

Ah. Missed off that rather important line at the end: “What our analysis shows is that a single dose of vaccine is highly protective”

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Re: Vaccine rollout in Nauru

Post by Herainestold » Tue May 18, 2021 9:20 pm

jdc wrote:
Tue May 18, 2021 7:56 pm
headshot wrote:
Tue May 18, 2021 5:54 pm
Herainestold wrote:
Tue May 18, 2021 5:11 pm


Data from Israel indicates you are more susceptible after the first dose for up to a week. After 2 weeks you should take precautions as if you are un vaccinated.
Citation please.
I think this may be what H is thinking of: https://www.medrxiv.org/content/10.1101 ... 21250957v1
After initial injection case numbers increased to day 8 before declining to low levels by day 21. Estimated vaccine effectiveness was pretty much 0 at day 14 but then rose to about 90% at day 21 before levelling off. The cause of the initial surge in infection risk is unknown but may be related to people being less cautious about maintaining protective behaviours as soon as they have the injection. What our analysis shows is that a single dose of vaccine is highly protective, although it can take up to 21 days to achieve this.
That must be it, although it is not exactly how I recalled it. Thanks, I couldn't find it, you are truly a service to this forum.

You are not considered fully vaccinated until two weeks after your second dose, so act accordingly.
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Re: Vaccine rollout in Nauru

Post by shpalman » Wed May 19, 2021 7:06 am

"fully vaccinated" is a pretty meaningless term, since even Pfizer doesn't give 100% protection x weeks after the nth dose.

But the publications do indicate that there's a decent amount of protection a few weeks after the first dose, both for Pfizer (1) and for AstraZeneca (2). I was originally critical of the UK's decision to not follow Pfizer's protocol but it turns out to have been a good call and various European countries are also considering leaving longer between doses. There may even be data indicating that leaving longer between Pfizer doses leads to greater overall efficacy.

Behaving as if you're unvaccinated isn't necessarily a terrible idea, for various reasons, but I don't think it's necessary to enforce it too hard.

1. see above

2. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

See also Effectiveness of First Dose of COVID-19 Vaccines Against Hospital Admissions in Scotland: National Prospective Cohort Study of 5.4 Million People.
having that swing is a necessary but not sufficient condition for it meaning a thing
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Herainestold
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Re: Vaccine rollout in Nauru

Post by Herainestold » Wed May 19, 2021 2:26 pm

shpalman wrote:
Wed May 19, 2021 7:06 am
"fully vaccinated" is a pretty meaningless term, since even Pfizer doesn't give 100% protection x weeks after the nth dose.

But the publications do indicate that there's a decent amount of protection a few weeks after the first dose, both for Pfizer (1) and for AstraZeneca (2). I was originally critical of the UK's decision to not follow Pfizer's protocol but it turns out to have been a good call and various European countries are also considering leaving longer between doses. There may even be data indicating that leaving longer between Pfizer doses leads to greater overall efficacy.

Behaving as if you're unvaccinated isn't necessarily a terrible idea, for various reasons, but I don't think it's necessary to enforce it too hard.

1. see above

2. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

See also Effectiveness of First Dose of COVID-19 Vaccines Against Hospital Admissions in Scotland: National Prospective Cohort Study of 5.4 Million People.
Yes, you have some reasonable protection two weeks after your first vax. As you point out even after full vaccinations, protection is not 100%.
So the question is, how should you act? In the face of this Indian variant, be cautious. After your first shot, do not resume any "normal" activities, stay masked, preferably double, keep distancing, don't go the pub. After the second dose, remember you are not invincible, be humble, be prudent, continue to mask and distance and protect your fellow citizen.
Masking forever
Putin is a monster.
Russian socialism will rise again

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Re: Vaccine rollout in Nauru

Post by headshot » Wed May 19, 2021 3:19 pm

Herainestold wrote:
Wed May 19, 2021 2:26 pm
shpalman wrote:
Wed May 19, 2021 7:06 am
"fully vaccinated" is a pretty meaningless term, since even Pfizer doesn't give 100% protection x weeks after the nth dose.

But the publications do indicate that there's a decent amount of protection a few weeks after the first dose, both for Pfizer (1) and for AstraZeneca (2). I was originally critical of the UK's decision to not follow Pfizer's protocol but it turns out to have been a good call and various European countries are also considering leaving longer between doses. There may even be data indicating that leaving longer between Pfizer doses leads to greater overall efficacy.

Behaving as if you're unvaccinated isn't necessarily a terrible idea, for various reasons, but I don't think it's necessary to enforce it too hard.

1. see above

2. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

See also Effectiveness of First Dose of COVID-19 Vaccines Against Hospital Admissions in Scotland: National Prospective Cohort Study of 5.4 Million People.
Yes, you have some reasonable protection two weeks after your first vax. As you point out even after full vaccinations, protection is not 100%.
So the question is, how should you act? In the face of this Indian variant, be cautious. After your first shot, do not resume any "normal" activities, stay masked, preferably double, keep distancing, don't go the pub. After the second dose, remember you are not invincible, be humble, be prudent, continue to mask and distance and protect your fellow citizen.
Tell me, have you ever walked down the stairs or crossed a road?

Herainestold
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Re: Vaccine rollout in Nauru

Post by Herainestold » Wed May 19, 2021 3:35 pm

headshot wrote:
Wed May 19, 2021 3:19 pm
Herainestold wrote:
Wed May 19, 2021 2:26 pm
shpalman wrote:
Wed May 19, 2021 7:06 am
"fully vaccinated" is a pretty meaningless term, since even Pfizer doesn't give 100% protection x weeks after the nth dose.

But the publications do indicate that there's a decent amount of protection a few weeks after the first dose, both for Pfizer (1) and for AstraZeneca (2). I was originally critical of the UK's decision to not follow Pfizer's protocol but it turns out to have been a good call and various European countries are also considering leaving longer between doses. There may even be data indicating that leaving longer between Pfizer doses leads to greater overall efficacy.

Behaving as if you're unvaccinated isn't necessarily a terrible idea, for various reasons, but I don't think it's necessary to enforce it too hard.

1. see above

2. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

See also Effectiveness of First Dose of COVID-19 Vaccines Against Hospital Admissions in Scotland: National Prospective Cohort Study of 5.4 Million People.
Yes, you have some reasonable protection two weeks after your first vax. As you point out even after full vaccinations, protection is not 100%.
So the question is, how should you act? In the face of this Indian variant, be cautious. After your first shot, do not resume any "normal" activities, stay masked, preferably double, keep distancing, don't go the pub. After the second dose, remember you are not invincible, be humble, be prudent, continue to mask and distance and protect your fellow citizen.
Tell me, have you ever walked down the stairs or crossed a road?
I am just so afraid that we are going to lose all the progress we have made to this new variant, in the light of an incautious re-opening.
There have been horrible policies on the part of our leaders, we know all that. We got the vaccination program right, and the roadmap was the right way to go, now at a critical point, we see new cases from a new variant, and instead of stepping back and locking down and dealing with it, we are going ahead. Madness. It is up to each of us as individuals to do whatever small thing we can to mitigate this new wave.
Masking forever
Putin is a monster.
Russian socialism will rise again

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