"Vaccines are wearing off"

Covid-19 discussion, bring your own statistics
purplehaze
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Re: "Vaccines are wearing off"

Post by purplehaze » Wed Sep 22, 2021 11:05 am

'Not having antibodies doesn't mean the vaccine has worn off, it just means the antibody part of the response is fading as per normal.'

Thank you for responding, that helps.

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Woodchopper
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Re: "Vaccines are wearing off"

Post by Woodchopper » Wed Sep 22, 2021 1:58 pm

purplehaze wrote:
Wed Sep 22, 2021 11:05 am
'Not having antibodies doesn't mean the vaccine has worn off, it just means the antibody part of the response is fading as per normal.'

Thank you for responding, that helps.
Yes, and that is what I would have written as well.

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jimbob
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Re: "Vaccines are wearing off"

Post by jimbob » Fri Oct 01, 2021 11:27 am

lpm wrote:
Wed Sep 22, 2021 10:18 am
You'll be getting a Pfizer. Unless you get a Moderna. No AZs for the booster program.

It will be six months after your second, i.e. in November.

Not having antibodies doesn't mean the vaccine has worn off, it just means the antibody part of the response is fading as per normal.
Yes there was a blogpost I saw about that from someone's link probably from here, explaining that.

Related to that, a friend has asked me to look at the numbers in this preprint, but I don't have time and it's pretty relevant to this subject

https://www.medrxiv.org/content/10.1101 ... 21264260v1
The impact of SARS-CoV-2 vaccination on Alpha and Delta variant transmission
Abstract
Background Pre-Delta, vaccination reduced transmission of SARS-CoV-2 from individuals infected despite vaccination, potentially via reducing viral loads. While vaccination still lowers the risk of infection, similar viral loads in vaccinated and unvaccinated individuals infected with Delta question how much vaccination prevents onward transmission. Methods We performed a retrospective observational cohort study of contacts of SARS-CoV-2-infected index cases using contact testing data from England. We used multivariable logistic regression to investigate the impact of index case and contact vaccination on transmission, and how this varies with Alpha and Delta variants (classified using S-gene detection/calendar trends) and time since second vaccination. Results 51,798/139,164(37.2%) contacts tested were PCR-positive. Two doses of BNT162b2 or ChAdOx1 vaccines in Alpha variant index cases independently reduced PCR-positivity in contacts (aOR, adjusted odds ratio vs. unvaccinated=0.18[95%CI 0.12-0.29] and 0.37[0.22-0.63] respectively). The Delta variant attenuated vaccine-associated reductions in transmission: two BNT162b2 doses reduced Delta transmission (aOR=0.35[0.26-0.48]), more than ChAdOx1 (aOR=0.64[0.57-0.72]; heterogeneity p<0.001). Variation in viral load (Ct values) explained only a modest proportion of vaccine-associated transmission reductions. Transmission reductions declined over time since second vaccination, for Delta reaching similar levels to unvaccinated individuals by 12 weeks for ChAdOx1 and attenuating substantially for BNT162b2. Protection from vaccination in contacts also declined in the 3 months after second vaccination. Conclusions Vaccination reduces transmission of Delta, but by less than the Alpha variant. The impact of vaccination decreased over time. Factors other than PCR-measured viral load are important in vaccine-associated transmission reductions. Booster vaccinations may help control transmission together with preventing infections.
As an aside, that's very long compared to the sort of Abstracts I'm used to seeing
Have you considered stupidity as an explanation

purplehaze
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Re: "Vaccines are wearing off"

Post by purplehaze » Fri Oct 01, 2021 12:44 pm

The letter in response to my negative response is very long and comprehensive, for which I'm also thankful.

It does implicitly emphasise that you should still follow current government advice and guidance on controlling the spread of the disease, including social distancing.

My nose and throat swabs are PCR.

My blood tests are CE marked by the MHRA.

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