Nuvaxovid

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tom p
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Nuvaxovid

Post by tom p » Mon Dec 20, 2021 2:12 pm

The EMA has just recommended Novavax's COVID vaccine Nuvaxoid for conditional marketing authorisation in the EEA.
90% efficacy & the studies were conducted when original strain + alpha & beta variants were circulating.
No data on omicron efficacy.
It's an old-fashioned vaccine: spike proteins plus adjuvants to boost immune response.

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jimbob
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Re: Nuvaxovid

Post by jimbob » Mon Dec 20, 2021 4:15 pm

tom p wrote:
Mon Dec 20, 2021 2:12 pm
The EMA has just recommended Novavax's COVID vaccine Nuvaxoid for conditional marketing authorisation in the EEA.
90% efficacy & the studies were conducted when original strain + alpha & beta variants were circulating.
No data on omicron efficacy.
It's an old-fashioned vaccine: spike proteins plus adjuvants to boost immune response.
Would it be good to provide a primer of the different flavours of Covid vaccine? I gather the Oxford/AZ (and Sputnik - which might have involved industrial espionage*) are also unconventional, but in a different way to the Pfizer-BnT or Moderna vaccines.



*Not sure of the credibility of it, but it would be on brand for Russia.
Have you considered stupidity as an explanation

Herainestold
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Re: Nuvaxovid

Post by Herainestold » Mon Dec 20, 2021 5:30 pm

Is there any indication of where and when it might be used?
I presume we won't really know how it stacks up against the m RNA vaxes until we have some usage data.
Masking forever
Putin is a monster, Russian people are not.

Herainestold
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Re: Nuvaxovid

Post by Herainestold » Tue Dec 21, 2021 12:20 am

Germany is going to use it.
Across Europe, but in particular in Germany, experts are hoping that both vaccines will have the effect of persuading those who have so far turned down the offer of a vaccine to change their minds, at a time when raising immunity levels by vaccination is one of the key weapons against halting the virus’s spread. So far, just over 70% of Germans are fully vaccinated. Unless this figure climbs to between 80 to 90%, the nation’s immunity will not be high enough to dampen the virus.

In a survey by the German pollster Forsa this autumn, 56% of participants said their vaccine willingness would rise if vaccines based on so-called “classical methods”, such as Novavax and Valneva, were approved. Only 5% said they would be lured to have a vaccination by monetary reward or the threat of being excluded from activities as a result of their unvaccinated status.
The government has ordered 60m doses of Novavax ahead of its expected approval.
Novavax expected to be become fourth Covid vaccine available in UK
Read more

About 14 million German adults are yet to have the first two doses of a Covid vaccine. However, in a survey of unvaccinated people, 40% said they were merely hesitant and could indeed be persuaded if “dead vaccines” were available to them.

Nevertheless, experts have warned against expecting a significant rise in those willing to receive Novavax or Valneva jabs.
https://www.theguardian.com/world/2021/ ... -nuvaxovid
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Sciolus
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Re: Nuvaxovid

Post by Sciolus » Tue Dec 21, 2021 9:10 am

I never dreamt that so many people were so knowledgeable about the pros and cons of different vaccine manufacturing technologies.

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bjn
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Re: Nuvaxovid

Post by bjn » Tue Dec 21, 2021 9:12 am

Sciolus wrote:
Tue Dec 21, 2021 9:10 am
I never dreamt that so many people were so knowledgeable about the pros and cons of different vaccine manufacturing technologies.
Fear of the new and the naturalism fallacy make for irrational decisions.

tom p
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Re: Nuvaxovid

Post by tom p » Tue Dec 21, 2021 4:20 pm

Herainestold wrote:
Mon Dec 20, 2021 5:30 pm
Is there any indication of where and when it might be used?
I presume we won't really know how it stacks up against the m RNA vaxes until we have some usage data.
Well, clinical trials, which give us the most accurate data, showed it to be about 90% effective, so slightly less good than the mRNA ones, but still excellent efficacy.
Now, clinical trials are an imperfect model for reality; but they all tend to be biased in pretty much the same way, so relative efficacy differences in clinical trials offer a pretty good comaprisson.

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Opti
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Re: Nuvaxovid

Post by Opti » Tue Dec 21, 2021 4:52 pm

tom p wrote:
Tue Dec 21, 2021 4:20 pm
[ ...
Now, clinical trials are an imperfect model for reality; but they all tend to be biased in pretty much the same way, so relative efficacy differences in clinical trials offer a pretty good comaprisson.
tom, do you know offhand what the storage and handling requirements are for the new vax? Sorry, just cba to find out myself.

I don't imagine it will make much of a dent here in Spain, the vaccine resisters aren't particularly put off by mRNA shots, they're just anti-vaxxers.
Just about everyone here who is going to get vaccinated already is.

I was just thinking about global distribution of an effective vaccine.
Time for a big fat one.

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Opti
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Re: Nuvaxovid

Post by Opti » Tue Dec 21, 2021 5:23 pm

Sorry tom, too slow, I just found out myself. Normal fridge temperature, that's a big plus.
Time for a big fat one.

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shpalman
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Re: Nuvaxovid

Post by shpalman » Tue Dec 21, 2021 5:36 pm

Not sure about calling it Novaxcovid though.
molto tricky

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sTeamTraen
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Re: Nuvaxovid

Post by sTeamTraen » Thu Dec 30, 2021 11:23 am

Herainestold wrote:
Tue Dec 21, 2021 12:20 am
In a survey by the German pollster Forsa this autumn, 56% of participants said their vaccine willingness would rise if vaccines based on so-called “classical methods”, such as Novavax and Valneva, were approved.
That sounds very much like the kind of poll where if you invert the framing of the question you get the opposite answer.

I suspect that if the AZ technology had been the dominant one, we would have analogous efforts to discredit that too. IIRC it uses a deactivated chimpanzee virus, which would provide top racist banter fodder. And it only costs $3, so "there must be something wrong with it", "corners must of been cut", etc.
Something something hammer something something nail

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shpalman
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Re: Nuvaxovid

Post by shpalman » Thu Dec 30, 2021 12:36 pm

sTeamTraen wrote:
Thu Dec 30, 2021 11:23 am
Herainestold wrote:
Tue Dec 21, 2021 12:20 am
In a survey by the German pollster Forsa this autumn, 56% of participants said their vaccine willingness would rise if vaccines based on so-called “classical methods”, such as Novavax and Valneva, were approved.
That sounds very much like the kind of poll where if you invert the framing of the question you get the opposite answer.

I suspect that if the AZ technology had been the dominant one, we would have analogous efforts to discredit that too. IIRC it uses a deactivated chimpanzee virus, which would provide top racist banter fodder. And it only costs $3, so "there must be something wrong with it", "corners must of been cut", etc.
"We don't know if it works in older people because it hasn't been tested", "It causes fatal blood clots in younger people" etc.
molto tricky

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