BA.2.75.2 and BQ.1.1

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Woodchopper
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BA.2.75.2 and BQ.1.1

Post by Woodchopper » Sat Sep 17, 2022 12:35 pm

Seems to be one to look out for.

Immune escape in Swedish blood donors: https://twitter.com/benjmurrell/status/ ... Pl5J93VdpQ

Background and links to other threads: https://twitter.com/mike_honey_/status/ ... KZ_YDzEYAg

Looks like it’s the fastest growing UK variant: https://twitter.com/peacockflu/status/1 ... j2pDicSGFg

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Re: BA.2.75.2 and BQ.1.1

Post by Woodchopper » Sat Sep 24, 2022 6:51 am

Update here: https://twitter.com/yunlong_cao/status/ ... zf796Nc9fA

I adjusted the thread title as BQ.1.1 is also worrying.

Good summary by the excellent Emma Hodcroft: https://twitter.com/firefoxx66/status/1 ... jxRv7HYB1Q

Some discussion:
https://twitter.com/twenseleers/status/ ... jxRv7HYB1Q

And some commentary: https://www.theguardian.com/world/2022/ ... cases-rise

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Re: BA.2.75.2 and BQ.1.1

Post by Woodchopper » Sun Sep 25, 2022 9:13 pm

looking like Omicron has a remarkable capacity for more evolution. One of the newest subvariants, called BA.2.75.2, can evade immune responses better than all earlier forms of Omicron.

For now, BA.2.75.2 is extremely rare, making up just .05 percent of the coronaviruses that have been sequenced worldwide in the past three months. But that was once true of other Omicron subvariants that later came to dominate the world. If BA.2.75.2 becomes widespread this winter, it may blunt the effectiveness of the newly authorized boosters from Moderna and Pfizer.

[…]

But it soon became clear that the name “Omicron” hid a complex reality. After the original Omicron virus evolved in the fall of 2021, its descendants split into at least five branches, known as BA.1 through BA.5.

[…]

The U.S. Food and Drug Administration responded by inviting vaccine makers to produce booster shots that included a BA.5 protein along with one from the original version of the virus. Those boosters are now rolling out to the public, at a time when BA.5 is causing 85 percent of all Covid cases in the United States.

But BA.5 could be fading in the rearview mirror by winter, scientists said. Omicron has continued to evolve — likely by sometimes jumping among hosts, and sometimes hiding for months in one of them.

Since these new lineages belong to Omicron, they haven’t gotten a Greek letter of their own. But that doesn’t mean they’re just a slight twist on the original. Antibodies that could latch onto earlier forms of Omicron fare poorly against the newer ones.

“They could arguably have been given different Greek letters,” Dr. Robertson said.

BA.2.75.2 is among the newest of Omicron’s grandchildren, identified just last month. It’s also the most evasive Omicron yet, according to Dr. Murrell. In lab experiments, he and his colleagues tested BA.2.75.2 against 13 monoclonal antibodies that are either in clinical use or in development. It evaded all but one of them, bebtelovimab, made by Eli Lilly.

They also tested the antibodies from recent blood donors in Sweden. BA.2.75.2 did substantially better at escaping those defenses than other Omicron subvariants did.

The researchers posted their study online on Friday. Researchers at Peking University reached similar conclusions in a study posted the same day. Both have yet to be published in a scientific journal.

Dr. Murrell cautioned that scientists have yet to run experiments that will show the effectiveness of BA.5 booster shots against BA.2.75.2. He suspected that getting a big supply of BA.5 antibodies would provide some protection, especially against severe disease.

“It’s still important, but we’ll have to wait for the data to come out to see exactly what the magnitude of the boosting effect is,” Dr. Murrell said.

There’s no reason to expect that BA.2.75.2 will be the end of the evolutionary line. As immunity builds to previous versions of Omicron, new versions will be able to evolve that can evade it.

“I don’t think it’s going to hit a wall in the mutational space,” said Daniel Sheward, a postdoctoral researcher at the Karolinska Institute and co-author on the new study.

Lorenzo Subissi, an infectious disease expert with the W.H.O., said that the organization was not giving Greek letters to lineages like BA.2.75.2 because they are much like the original Omicron viruses. For example, it appears that all Omicron lineages use a distinctive route to get into cells. As a result, it is less likely to lead to severe infections but possibly better able to spread than previous variants.

“W.H.O. only names a variant when it is concerned that additional risks are being created that require new public health action,” Dr. Subissi said. But he did not rule out a Pi in our future.

“This virus still remains largely unpredictable,” he said.
https://www.nytimes.com/2022/09/22/scie ... riant.html

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Re: BA.2.75.2 and BQ.1.1

Post by Woodchopper » Mon Sep 26, 2022 2:57 pm

Growth in Denmark, Belgium and England: https://twitter.com/JosetteSchoenma/sta ... n8qUagGPmQ

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Re: BA.2.75.2 and BQ.1.1

Post by Woodchopper » Wed Sep 28, 2022 5:13 am

Big COVID-19 waves may be coming, new Omicron strains suggest
https://www.science.org/content/article ... ns-suggest

Summary of what is known so far.

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Re: BA.2.75.2 and BQ.1.1

Post by Woodchopper » Wed Sep 28, 2022 7:55 am


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