BREAKING NEWS: People can get infected from asymptomatic and pre-symptomatic carriers but we don't know how much
"Ought to figure it out and do something about it"
Brought to you by our "weird, this seems to have a timestamp from now and not from a year ago" desk.
COVID-19
Re: COVID-19
molto tricky
- Woodchopper
- Stummy Beige
- Posts: 2962
- Joined: Sat Oct 12, 2019 9:05 am
Re: COVID-19
https://insight.jci.org/articles/view/146316
A majority of uninfected adults show pre-existing antibody reactivity against SARS-CoV-2
Pre-existing cross-reactivity to SARS-CoV-2 may occur in absence of prior viral exposure. However, this has been difficult to quantify at the population level due to a lack of reliably defined seroreactivity thresholds. Using an orthogonal antibody testing approach, we estimated that ~0.6% of non-triaged adults from the greater Vancouver area, Canada between May 17th and June 19th 2020 showed clear evidence of a prior SARS-CoV-2 infection, after adjusting for false-positive and false-negative test results. Using a highly sensitive multiplex assay and positive/negative thresholds established in infants in whom maternal antibodies have waned, we determine that more than 90% of uninfected adults showed antibody reactivity against the spike, receptor-binding domain (RBD), N-terminal domains (NTD) or the nucleocapsid (N) protein from SARS-CoV-2. This sero-reactivity was evenly distributed across age and sex, correlated with circulating coronaviruses reactivity, and was partially outcompeted by soluble circulating coronaviruses’ spike. Using a custom SARS-CoV-2 peptide mapping array, we found that this antibody reactivity broadly mapped to spike, and to conserved non-structural viral proteins. We conclude that most adults display pre-existing antibody cross-reactivity against SARS-CoV-2, which further supports investigation of how this may impact the clinical severity of COVID-19 or SARS-CoV-2 vaccine responses.
- bob sterman
- Snowbonk
- Posts: 418
- Joined: Mon Nov 11, 2019 10:25 pm
Re: COVID-19
I wonder how James Annan will adjust the model he fits to ONS data in light of this (now deleted tweet from the company collecting data on behalf of the ONS)...
- tenchboy
- Catbabel
- Posts: 767
- Joined: Tue Nov 12, 2019 5:18 pm
- Location: Down amongst the potamogeton.
Re: COVID-19
Aaaaaaand we are back to normal; pandemic obviously over; virus obviously gone home.
Why?
Cos I just had a royal mail recorded signed for delivery and t postie said sign this as he thrust an old fashioned neighbourhood flu spreader at me upon which to wipe my finger where everyone else had just wiped theirs.
I said no. Nicely of course.
That's why.
Why?
Cos I just had a royal mail recorded signed for delivery and t postie said sign this as he thrust an old fashioned neighbourhood flu spreader at me upon which to wipe my finger where everyone else had just wiped theirs.
I said no. Nicely of course.
That's why.