COVID-19

Covid-19 discussion, bring your own statistics
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shpalman
Stummy Beige
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Location: One step beyond

Re: COVID-19

Post by shpalman » Tue Apr 06, 2021 7:20 pm

BREAKING NEWS: People can get infected from asymptomatic and pre-symptomatic carriers but we don't know how much

"Ought to figure it out and do something about it"

Brought to you by our "weird, this seems to have a timestamp from now and not from a year ago" desk.
molto tricky

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Woodchopper
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Re: COVID-19

Post by Woodchopper » Tue Apr 06, 2021 8:12 pm


A majority of uninfected adults show pre-existing antibody reactivity against SARS-CoV-2

Pre-existing cross-reactivity to SARS-CoV-2 may occur in absence of prior viral exposure. However, this has been difficult to quantify at the population level due to a lack of reliably defined seroreactivity thresholds. Using an orthogonal antibody testing approach, we estimated that ~0.6% of non-triaged adults from the greater Vancouver area, Canada between May 17th and June 19th 2020 showed clear evidence of a prior SARS-CoV-2 infection, after adjusting for false-positive and false-negative test results. Using a highly sensitive multiplex assay and positive/negative thresholds established in infants in whom maternal antibodies have waned, we determine that more than 90% of uninfected adults showed antibody reactivity against the spike, receptor-binding domain (RBD), N-terminal domains (NTD) or the nucleocapsid (N) protein from SARS-CoV-2. This sero-reactivity was evenly distributed across age and sex, correlated with circulating coronaviruses reactivity, and was partially outcompeted by soluble circulating coronaviruses’ spike. Using a custom SARS-CoV-2 peptide mapping array, we found that this antibody reactivity broadly mapped to spike, and to conserved non-structural viral proteins. We conclude that most adults display pre-existing antibody cross-reactivity against SARS-CoV-2, which further supports investigation of how this may impact the clinical severity of COVID-19 or SARS-CoV-2 vaccine responses.
https://insight.jci.org/articles/view/146316

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bob sterman
Snowbonk
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Re: COVID-19

Post by bob sterman » Sat Apr 10, 2021 7:11 am

I wonder how James Annan will adjust the model he fits to ONS data in light of this (now deleted tweet from the company collecting data on behalf of the ONS)...

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EyjZgVgXMAYc9-t.png (396.17 KiB) Viewed 88 times

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tenchboy
Catbabel
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Location: Down amongst the potamogeton.

Re: COVID-19

Post by tenchboy » Sat Apr 10, 2021 12:47 pm

Aaaaaaand we are back to normal; pandemic obviously over; virus obviously gone home.
Why?
Cos I just had a royal mail recorded signed for delivery and t postie said sign this as he thrust an old fashioned neighbourhood flu spreader at me upon which to wipe my finger where everyone else had just wiped theirs.
I said no. Nicely of course.
That's why.

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