Developing the Covid-19 vaccine

Covid-19 discussion, bring your own statistics
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Woodchopper
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Re: Developing the Covid-19 vaccine

Post by Woodchopper » Wed Aug 26, 2020 7:47 pm

As the coronavirus pandemic continues to wreak havoc in the United States and treatments are needed more than ever, clinical trials for some of the most promising experimental drugs are taking longer than expected.

Researchers at a dozen clinical trial sites said that testing delays, staffing shortages, space constraints and reluctant patients were complicating their efforts to test monoclonal antibodies, man-made drugs that mimic the molecular soldiers made by the human immune system.

As a result, once-ambitious deadlines are slipping. The drug maker Regeneron, which previously said it could have emergency doses of its antibody cocktail ready by the end of summer, has shifted to talking about how “initial data” could be available by the end of September.

And Eli Lilly’s chief scientific officer said in June that its antibody treatment might be ready in September, but in an interview this week, he said he now hopes for something before the end of the year.
https://www.nytimes.com/2020/08/14/heal ... e=Homepage

Lew Dolby
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Re: Developing the Covid-19 vaccine

Post by Lew Dolby » Sat Sep 05, 2020 6:14 pm

Again the NYTimes - this is tracking where we are with vaccines.

https://www.nytimes.com/interactive/202 ... ments.html

[not my area but looks pukka]

[eta the actual link - duh !!]
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jdc
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Re: Developing the Covid-19 vaccine

Post by jdc » Sat Sep 05, 2020 6:59 pm

That's actually their treatment tracker. Their vaccine tracker is here: https://www.nytimes.com/interactive/202 ... acker.html

Lew Dolby
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Re: Developing the Covid-19 vaccine

Post by Lew Dolby » Sat Sep 05, 2020 7:12 pm

sorry, my mistook.
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Herainestold
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Re: Developing the Covid-19 vaccine

Post by Herainestold » Tue Sep 08, 2020 4:55 am

The Chinese have developed a viable vaccine.
Chinese drug firm says hundreds of thousands have been given Covid-19 vaccines without a single case of infection

An official from China National Biotec Group says the evidence from an emergency use scheme suggests the products are working
Company is also confident its vaccines can offer protection for up to three years
Zhou Song, secretary for the commission for discipline inspection with China National Biotec Group, also said the company’s two candidate vaccines were likely to protect people for up to three years.

Zhou told China National Radio on Monday that the firm’s vaccines were the most widely used in the emergency scheme, adding: “Hundreds of thousands have taken the shot and no one has shown any obvious adverse events or got infected.”

CNBG’s two vaccines are still undergoing phase three trials for safety and efficacy in several countries, including the United Arab Emirates, Bahrain, Peru, Morocco, Argentina and Jordan.

China’s emergency vaccine scheme began in late July and allows high-risk groups – including health care workers, diplomats and people who work abroad – to receive vaccines that have not yet been approved by regulators.
https://www.scmp.com/news/china/society ... gn=3100570

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Woodchopper
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Re: Developing the Covid-19 vaccine

Post by Woodchopper » Thu Sep 10, 2020 2:30 am

Some good commentary on the serious adverse event which paused the Oxford/AstraZeneca vaccine trial
https://blogs.sciencemag.org/pipeline/a ... event-time

EACLucifer
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Re: Developing the Covid-19 vaccine

Post by EACLucifer » Thu Sep 10, 2020 10:42 am

Herainestold wrote:
Tue Sep 08, 2020 4:55 am
The lying totalitarian state that lied about this virus in the first place is claiming to have a viable vaccine, but in practise it's still in trials just like all the others
Fixed it for you you tyrannophile imbecile.

noggins
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Re: Developing the Covid-19 vaccine

Post by noggins » Thu Sep 10, 2020 1:19 pm

Woodchopper wrote:
Thu Sep 10, 2020 2:30 am
Some good commentary on the serious adverse event which paused the Oxford/AstraZeneca vaccine trial
https://blogs.sciencemag.org/pipeline/a ... event-time
Philosophical-statistical (?) question - if 999 test subjects are fine and 1 develops a Terrible Health Problem, do you consider the rarity of that specific problem, or the rarity of someone developing Any serious health issue?

Herainestold
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Re: Developing the Covid-19 vaccine

Post by Herainestold » Thu Sep 10, 2020 5:56 pm

I predicted the Chinese would be first out of the gate in the vaccine sweepstakes. Unfortunate about the Astra Zeneca adverse advent, looks like they are out of the running. Maybe one of the other Western efforts will fill the gap.

AMS
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Re: Developing the Covid-19 vaccine

Post by AMS » Thu Sep 10, 2020 7:27 pm

Herainestold wrote:
Thu Sep 10, 2020 5:56 pm
I predicted the Chinese would be first out of the gate in the vaccine sweepstakes. Unfortunate about the Astra Zeneca adverse advent, looks like they are out of the running. Maybe one of the other Western efforts will fill the gap.
Do you trust the Chinese government to report any adverse events?

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Bird on a Fire
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Re: Developing the Covid-19 vaccine

Post by Bird on a Fire » Thu Sep 10, 2020 7:39 pm

We can't even trust them to report a pandemic.
Born at 356.32 ppm CO2 #ShowYourStripes

EACLucifer
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Re: Developing the Covid-19 vaccine

Post by EACLucifer » Thu Sep 10, 2020 8:21 pm

Herainestold wrote:
Thu Sep 10, 2020 5:56 pm
I predicted the Chinese would be first out of the gate in the vaccine sweepstakes. Unfortunate about the Astra Zeneca adverse advent, looks like they are out of the running. Maybe one of the other Western efforts will fill the gap.
1) You are bootlicker for a fascist regime. Of course you fawn over them and their efforts, you utter pustule.

2) No, the AstraZeneca vaccine isn't done yet, unless I missed something big in the last few hours, there's still a lot of uncertainty

3) Fascist state can be no more trusted than fascist bootlickers. As has been pointed out by others, how can a country be trusted to report adverse events when instead of reporting a pandemic, they sent thugs to beat up doctors for discussing it in a private webchat, let alone notifying the world like a reasonable country.

4) Not only can they not be trusted to be honest about adverse events, they can't be trusted to care about people at all. They are currently trying to destroy Uighur culture, and now look to be trying similar to the Mongols.

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sTeamTraen
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Re: Developing the Covid-19 vaccine

Post by sTeamTraen » Thu Sep 10, 2020 11:23 pm

Herainestold wrote:
Thu Sep 10, 2020 5:56 pm
I predicted the Chinese would be first out of the gate in the vaccine sweepstakes. Unfortunate about the Astra Zeneca adverse advent, looks like they are out of the running. Maybe one of the other Western efforts will fill the gap.
You do realise that we don't even know yet if the adverse event was in the control group?

It is completely normal for medical trials to have adverse events. People have heart attacks or get cancer during trials. That may or may not have anything to do with the trial or the treatment. Even if the treatment does have side effects, decisions need to be taken about their acceptability. And at least we get to hear about them. I'm currently involved in discussions about whether the Russian vaccine (rolling out very soon) is based on fake trial data - it's unclear, but there are some patterns in there that at least require explanation.
Careering along in my creosote car

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jdc
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Re: Developing the Covid-19 vaccine

Post by jdc » Fri Sep 11, 2020 12:38 am

sTeamTraen wrote:
Thu Sep 10, 2020 11:23 pm

You do realise that we don't even know yet if the adverse event was in the control group?

Dunno how reliable this site is but they reckon we do know: https://www.statnews.com/2020/09/09/ast ... nt-report/
The participant who triggered a global shutdown of AstraZeneca’s Phase 3 Covid-19 vaccine trials was a woman in the United Kingdom who experienced neurological symptoms consistent with a rare but serious spinal inflammatory disorder called transverse myelitis, the drug maker’s chief executive, Pascal Soriot, said during a private conference call with investors on Wednesday morning.

The woman’s diagnosis has not been confirmed yet, but she is improving and will likely be discharged from the hospital as early as Wednesday, Soriot said.

The board tasked with overseeing the data and safety components of the AstraZeneca clinical trials confirmed that the participant was injected with the company’s Covid-19 vaccine and not a placebo, Soriot said on the conference call, which was set up by the investment bank J.P. Morgan.

Herainestold
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Re: Developing the Covid-19 vaccine

Post by Herainestold » Fri Sep 11, 2020 5:11 am

We should be re assured that the system is working. That is why trials with thousands of participants are necessary, to rout out very rare but potentially serious side effects. If this report is true, and it can be shown that it was likely caused by the vaccine, then this effort is finished.
There are a number of vaccine candidates being tested, it is likely that one of them will be safe enough to administer.

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headshot
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Re: Developing the Covid-19 vaccine

Post by headshot » Sat Sep 12, 2020 3:47 pm

The Oxford vaccine trial has resumed. So that’s excellent news.

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