Developing the Covid-19 vaccine

Covid-19 discussion, bring your own statistics
EACLucifer
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Re: Developing the Covid-19 vaccine

Post by EACLucifer » Wed Mar 18, 2020 10:46 pm

Again with treatment not vaccine, but the WHO is trying a similar approach to the one they took with the recent Ebola outbreak.

Candidates are remdesivir, lopinavir and ritonavir; lopinavir and ritonavir plus interferon beta, and chloroquine.

AMS
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Re: Developing the Covid-19 vaccine

Post by AMS » Thu Mar 19, 2020 8:25 am

I think some of the pharmas are also looking for monoclonal antibodies that block the virus from infecting cells. It's not tried and tested stuff, but people have looked at inhaler-style delivery routes. It will take longer than repurposing existing meds, though.

Herainestold
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Re: Developing the Covid-19 vaccine

Post by Herainestold » Thu Mar 19, 2020 9:40 pm

The Chinese military has been working on a vaccine.
“China’s announcement of a clinical trial came a little bit earlier than I had expected, even though I believe the first dose of the recombinant vaccine has already been injected into Chen’s body and some of her teammates,” Tao Lina, a Shanghai-based vaccine expert, said.

Tao was referring to photos that have been circulating on the social media platform WeChat that showed Chen being injected with a possible vaccine.
China developing 9 potential vaccines in global race for coronavirus cure
19 Mar 2020

Chen, 54 specialises in the development of recombinant vaccines – which use a harmless virus or bacterium to introduce the pathogen’s genetic material into the body to build up immunity – and has been credited with helping develop treatments during the 2014-16 Ebola outbreak.

She also developed a nasal spray to protect medical workers during the 2002-03 outbreak of severe acute respiratory syndrome (Sars).

The Chinese military has also been helping to tackle the medical emergency in Hubei, the province at the centre of the outbreak, with more than 10,000 personnel being deployed.

https://www.scmp.com/news/china/militar ... ce-develop


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Woodchopper
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Re: Developing the Covid-19 vaccine

Post by Woodchopper » Tue Jul 07, 2020 11:50 am

Actually it’s only 6% who stated that they definitely would not.
https://docs.cdn.yougov.com/5mkju0kxbj/ ... 002%29.pdf

Though another 10% probably would not. Hopefully they could be persuaded.

Millennie Al
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Re: Developing the Covid-19 vaccine

Post by Millennie Al » Wed Jul 08, 2020 2:10 am

Covid-19 - Don't catch it: don't spread it.

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shpalman
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Re: Developing the Covid-19 vaccine

Post by shpalman » Mon Jul 20, 2020 3:45 pm

molto tricky

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snoozeofreason
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Re: Developing the Covid-19 vaccine

Post by snoozeofreason » Mon Jul 20, 2020 4:24 pm

shpalman wrote:
Mon Jul 20, 2020 3:45 pm
The Oxford vaccine seems to work.
But for some reason your link doesn't, even though it seems correct. Try copying

Code: Select all

https://www.thelancet.com/lancet/article/s0140-6736(20)31604-4
into the address bar of a browser
In six days the Lord made the heavens and the earth, the sea, and all that is in them. The human body was knocked up pretty late on the Friday afternoon, with a deadline looming. How well do you expect it to work?

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shpalman
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Re: Developing the Covid-19 vaccine

Post by shpalman » Mon Jul 20, 2020 4:37 pm

STUPID f.cking c.nting BRACKETS IN DOIs coupled with phpBB being "helpful" that's why
molto tricky

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Gfamily
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Re: Developing the Covid-19 vaccine

Post by Gfamily » Mon Jul 20, 2020 4:39 pm

shpalman wrote:
Mon Jul 20, 2020 4:37 pm
STUPID f.cking c.nting BRACKETS IN DOIs coupled with phpBB being "helpful" that's why
I was going to say something similar, except it was more along the lines of
replace %28 by (
and replace %29 by )
My avatar was a scientific result that was later found to be 'mistaken' - I rarely claim to be 100% correct
ETA 5/8/20: I've been advised that the result was correct, it was the initial interpretation that needed to be withdrawn
Meta? I'd say so!

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shpalman
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Re: Developing the Covid-19 vaccine

Post by shpalman » Mon Jul 20, 2020 4:41 pm

Gfamily wrote:
Mon Jul 20, 2020 4:39 pm
shpalman wrote:
Mon Jul 20, 2020 4:37 pm
STUPID f.cking c.nting BRACKETS IN DOIs coupled with phpBB being "helpful" that's why
I was going to say something similar, except it was more along the lines of
replace %28 by (
and replace %29 by )
They were f.cking brackets when they left here.
molto tricky

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discovolante
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Re: Developing the Covid-19 vaccine

Post by discovolante » Mon Jul 20, 2020 10:06 pm

Can someone who is more knowledgeable than me explain how a vaccine would overcome the apparent fact that antibodies from infection don't seem to be lasting that long? Asks she who knows very little about vaccines despite 12 years hanging around here.
don't get any big ideas, they're not gonna happen

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Gfamily
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Re: Developing the Covid-19 vaccine

Post by Gfamily » Mon Jul 20, 2020 10:23 pm

discovolante wrote:
Mon Jul 20, 2020 10:06 pm
Can someone who is more knowledgeable than me explain how a vaccine would overcome the apparent fact that antibodies from infection don't seem to be lasting that long? Asks she who knows very little about vaccines despite 12 years hanging around here.
It's a good question, and I don't know if this helps
https://www.technologynetworks.com/immu ... ces-293550

tl:dr is that the vaccine causes not only an immediate creation of antibodies by B cells, but also the development of 'Memory B cells', which mean the body can make a much faster response to future infection
My avatar was a scientific result that was later found to be 'mistaken' - I rarely claim to be 100% correct
ETA 5/8/20: I've been advised that the result was correct, it was the initial interpretation that needed to be withdrawn
Meta? I'd say so!

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sTeamTraen
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Re: Developing the Covid-19 vaccine

Post by sTeamTraen » Mon Jul 20, 2020 11:59 pm

The vaccine is called "ChAdOx1 nCoV-19", which I presume is what happens when you let your 12-year-old son and his pals name it.
Something something hammer something something nail

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basementer
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Re: Developing the Covid-19 vaccine

Post by basementer » Tue Jul 21, 2020 1:30 am

sTeamTraen wrote:
Mon Jul 20, 2020 11:59 pm
The vaccine is called "ChAdOx1 nCoV-19", which I presume is what happens when you let your 12-year-old son and his pals name it.
Looks like the name of Elon Musk's next child.
Money is just a substitute for luck anyway. - Tom Siddell

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discovolante
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Re: Developing the Covid-19 vaccine

Post by discovolante » Tue Jul 21, 2020 7:33 am

Gfamily wrote:
Mon Jul 20, 2020 10:23 pm
discovolante wrote:
Mon Jul 20, 2020 10:06 pm
Can someone who is more knowledgeable than me explain how a vaccine would overcome the apparent fact that antibodies from infection don't seem to be lasting that long? Asks she who knows very little about vaccines despite 12 years hanging around here.
It's a good question, and I don't know if this helps
https://www.technologynetworks.com/immu ... ces-293550

tl:dr is that the vaccine causes not only an immediate creation of antibodies by B cells, but also the development of 'Memory B cells', which mean the body can make a much faster response to future infection
Thank you, I'll have a read through that link later.
don't get any big ideas, they're not gonna happen

Herainestold
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Re: Developing the Covid-19 vaccine

Post by Herainestold » Tue Jul 21, 2020 3:56 pm

How will they decide who gets it, if and when it becomes available?

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sTeamTraen
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Re: Developing the Covid-19 vaccine

Post by sTeamTraen » Tue Jul 21, 2020 7:20 pm

Herainestold wrote:
Tue Jul 21, 2020 3:56 pm
How will they decide who gets it, if and when it becomes available?
The UK government has pre-ordered 100 million doses. I presume it will go to Michael Gove and his family first, then healthcare workers, then be offered to people over 65 or those with other pre-existing conditions. Maybe also schoolteachers?
Something something hammer something something nail

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Sciolus
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Re: Developing the Covid-19 vaccine

Post by Sciolus » Tue Jul 21, 2020 8:13 pm

As LPM (I think) pointed out, it *should* go to superspreaders first, which will provide more protection to the vulnerable than vaccinating them directly by stamping out the spread. So I presume that would include healthcare/care home workers, teachers, public transport workers etc.

The interesting question is which countries get it first.

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JQH
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Re: Developing the Covid-19 vaccine

Post by JQH » Tue Jul 21, 2020 8:33 pm

Those with the deepest pockets. Or one with a lunatic head of state sends its military in to snaffle the vaccine.

Today's script conference was a bit out there.
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jdc
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Re: Developing the Covid-19 vaccine

Post by jdc » Tue Jul 21, 2020 10:44 pm

discovolante wrote:
Mon Jul 20, 2020 10:06 pm
Can someone who is more knowledgeable than me explain how a vaccine would overcome the apparent fact that antibodies from infection don't seem to be lasting that long? Asks she who knows very little about vaccines despite 12 years hanging around here.
There seems to be a school of thought that we'll be needing revaccination.
Prof Sir John Bell, of the University of Oxford, said he thought it was unlikely that Covid-19 would ever be eliminated [...] "The vaccine is unlikely to have a durable effect that'll last for a very long time, so we're going to have to have a continual cycle of vaccinations, and then more disease, and more vaccinations and more disease."

Millennie Al
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Re: Developing the Covid-19 vaccine

Post by Millennie Al » Wed Jul 22, 2020 2:21 am

sTeamTraen wrote:
Mon Jul 20, 2020 11:59 pm
The vaccine is called "ChAdOx1 nCoV-19", which I presume is what happens when you let your 12-year-old son and his pals name it.
It uses a chimpanzee adenovirus developed at Oxford as a base. There are two of these, and it uses number 1. It combats a novel Coronavirus first seen in 2019. So, yes, naming may well have involved 12-year olds.

Some details at https://www.vaccitech.co.uk/technology/
Covid-19 - Don't catch it: don't spread it.

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Woodchopper
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Re: Developing the Covid-19 vaccine

Post by Woodchopper » Wed Jul 22, 2020 3:49 am

Millennie Al wrote:
Wed Jul 22, 2020 2:21 am
sTeamTraen wrote:
Mon Jul 20, 2020 11:59 pm
The vaccine is called "ChAdOx1 nCoV-19", which I presume is what happens when you let your 12-year-old son and his pals name it.
It uses a chimpanzee adenovirus developed at Oxford as a base. There are two of these, and it uses number 1. It combats a novel Coronavirus first seen in 2019. So, yes, naming may well have involved 12-year olds.

Some details at https://www.vaccitech.co.uk/technology/
Don’t tell the antivaxxers. As soon as they hear about humans being injected with a monkey virus they’ll go apeshit.

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headshot
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Re: Developing the Covid-19 vaccine

Post by headshot » Wed Jul 22, 2020 6:07 am

Woodchopper wrote:
Wed Jul 22, 2020 3:49 am
Millennie Al wrote:
Wed Jul 22, 2020 2:21 am
sTeamTraen wrote:
Mon Jul 20, 2020 11:59 pm
The vaccine is called "ChAdOx1 nCoV-19", which I presume is what happens when you let your 12-year-old son and his pals name it.
It uses a chimpanzee adenovirus developed at Oxford as a base. There are two of these, and it uses number 1. It combats a novel Coronavirus first seen in 2019. So, yes, naming may well have involved 12-year olds.

Some details at https://www.vaccitech.co.uk/technology/
Don’t tell the antivaxxers. As soon as they hear about humans being injected with a monkey virus they’ll go apeshit.
Do not rhesusitate?

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Gfamily
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Re: Developing the Covid-19 vaccine

Post by Gfamily » Wed Jul 22, 2020 7:50 am

headshot wrote:
Wed Jul 22, 2020 6:07 am
Woodchopper wrote:
Wed Jul 22, 2020 3:49 am
Don’t tell the antivaxxers. As soon as they hear about humans being injected with a monkey virus they’ll go apeshit.
Do not rhesusitate?
Very good
My avatar was a scientific result that was later found to be 'mistaken' - I rarely claim to be 100% correct
ETA 5/8/20: I've been advised that the result was correct, it was the initial interpretation that needed to be withdrawn
Meta? I'd say so!

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