Obesogens

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Re: Obesogens

Post by dyqik » Mon Jul 24, 2023 2:35 pm

shpalman wrote:
Mon Jul 24, 2023 2:11 pm
Visible six packs yet?
It's more about 4-packs around here.

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Re: Obesogens

Post by shpalman » Thu Jul 27, 2023 1:12 pm

shpalman wrote:
Thu May 18, 2023 6:45 am
works though
The report concluded that administering semaglutide once a week gave “historically unprecedented” results, and brought about “clinically meaningful improvements”.

“These results underscore the high degree of clinical effectiveness of semaglutide in adolescents with obesity.”
Reducing BMI below the obesity threshold in adolescents treated with once-weekly subcutaneous semaglutide 2.4 mg
Semaglutide was highly effective in reducing BMI category. While on treatment, most trial participants' BMI improved by at least one category, and >40% reached a category below the obesity threshold.
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Re: Obesogens

Post by shpalman » Thu Aug 10, 2023 10:07 am

The weight-loss jab Wegovy can reduce the risk of major cardiovascular events by 20% in people who are overweight or obese.
The results of the study were shared in a press release by Novo Nordisk rather than in a peer-reviewed research paper, meaning detail was limited – including to what extent the findings could be down to the direct effects of Wegovy, or indirect effects as a result of weight loss.
Still, it's good that the weight loss drug has a benefit concerning the poor health outcomes of being overweight and obese, rather than only reducing weight.
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Re: Obesogens

Post by Tessa K » Thu Aug 10, 2023 12:42 pm

shpalman wrote:
Thu Aug 10, 2023 10:07 am
The weight-loss jab Wegovy can reduce the risk of major cardiovascular events by 20% in people who are overweight or obese.
The results of the study were shared in a press release by Novo Nordisk rather than in a peer-reviewed research paper, meaning detail was limited – including to what extent the findings could be down to the direct effects of Wegovy, or indirect effects as a result of weight loss.
Still, it's good that the weight loss drug has a benefit concerning the poor health outcomes of being overweight and obese, rather than only reducing weight.
I listened to an Inside Health pod about this (BBC). It only works as long as the person keeps having it otherwise the weight comes back in almost everyone. The longterm effects are not yet known and it's expensive. It would be good eg for someone who needs to lose weight for surgery

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Re: Obesogens

Post by RoMo » Fri Aug 11, 2023 5:34 am

Tessa K wrote:
Thu Aug 10, 2023 12:42 pm

I listened to an Inside Health pod about this (BBC). It only works as long as the person keeps having it otherwise the weight comes back in almost everyone. The longterm effects are not yet known and it's expensive. It would be good eg for someone who needs to lose weight for surgery
Interesting article from Yoni Freedhoff here about semaglutide. Point 1 is that yes, if you stop taking it the weight will return, that's how treatment for chronic conditions work and no-one seems to mind for anything other than weight.

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Re: Obesogens

Post by Tessa K » Fri Aug 11, 2023 8:53 am

RoMo wrote:
Fri Aug 11, 2023 5:34 am
Tessa K wrote:
Thu Aug 10, 2023 12:42 pm

I listened to an Inside Health pod about this (BBC). It only works as long as the person keeps having it otherwise the weight comes back in almost everyone. The longterm effects are not yet known and it's expensive. It would be good eg for someone who needs to lose weight for surgery
Interesting article from Yoni Freedhoff here about semaglutide. Point 1 is that yes, if you stop taking it the weight will return, that's how treatment for chronic conditions work and no-one seems to mind for anything other than weight.
Partly because there's a moral judgment about obesity. Why should tax payer money be spent on something you should do for yourself?

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Re: Obesogens

Post by Martin_B » Fri Aug 11, 2023 9:18 am

RoMo wrote:
Fri Aug 11, 2023 5:34 am
Tessa K wrote:
Thu Aug 10, 2023 12:42 pm

I listened to an Inside Health pod about this (BBC). It only works as long as the person keeps having it otherwise the weight comes back in almost everyone. The longterm effects are not yet known and it's expensive. It would be good eg for someone who needs to lose weight for surgery
Interesting article from Yoni Freedhoff here about semaglutide. Point 1 is that yes, if you stop taking it the weight will return, that's how treatment for chronic conditions work and no-one seems to mind for anything other than weight.
[Anecdata] I was taking semaglutide and it led to me gaining weight. The side-effects of chronic indigestion (and low-grade diarrhea) led to a reduction in exercise and an increase in food uptake to combat the acid reflux. I've come off it and have started losing weight again! [/Anecdata]
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Re: Obesogens

Post by shpalman » Fri Aug 11, 2023 12:25 pm

There's some more anecdata at https://www.washingtonpost.com/health/2 ... y-ozempic/

But we do know what the long-term effects of obesity and/or type II diabetes are.
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Re: Obesogens

Post by shpalman » Fri Aug 18, 2023 6:52 am

having that swing is a necessary but not sufficient condition for it meaning a thing
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Re: Obesogens

Post by shpalman » Thu Sep 07, 2023 11:27 am

having that swing is a necessary but not sufficient condition for it meaning a thing
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Re: Obesogens

Post by shpalman » Sun Oct 08, 2023 9:47 am

having that swing is a necessary but not sufficient condition for it meaning a thing
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Re: Obesogens

Post by shpalman » Thu Oct 19, 2023 9:51 am

Food which makes you eat more https://elifesciences.org/articles/82446

I found this via a local news website which managed to link directly to the paper, unlike the self-important both-sides morons at places like the BBC or the Guardian.
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Re: Obesogens

Post by Tessa K » Thu Oct 19, 2023 10:48 am

shpalman wrote:
Thu Oct 19, 2023 9:51 am
Food which makes you eat more https://elifesciences.org/articles/82446

I found this via a local news website which managed to link directly to the paper, unlike the self-important both-sides morons at places like the BBC or the Guardian.
Can you give some examples of foods for non science people? The abstract mentioned baking but is that all?

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Re: Obesogens

Post by IvanV » Thu Oct 19, 2023 11:18 am

Tessa K wrote:
Thu Oct 19, 2023 10:48 am
shpalman wrote:
Thu Oct 19, 2023 9:51 am
Food which makes you eat more https://elifesciences.org/articles/82446

I found this via a local news website which managed to link directly to the paper, unlike the self-important both-sides morons at places like the BBC or the Guardian.
Can you give some examples of foods for non science people? The abstract mentioned baking but is that all?
This article refers to AGEs resulting from the Maillard reaction, which is the browning reaction that occurs in certain kinds of cooking. Whether its frying, baking, roasting, whether of pastry products, meat, potatoes, onions, veg, if it browned in cooking, that was the Maillard reaction, We all know that browning in cooking makes food tasty. It's why so many of us love barbecues, chips, the crust on bread, things with browned cheesy toppings, things cooked in breadcrumbs, etc.

This article makes the unsurprising connection that eating such tasty food encourages us to eat more than eating bland food. That tastes very nice, I'll have another one please.

On the more general point of whether AGEs are good for you or bad for you, which all Mail-readers will wish to know, they can be put in both columns, as the wiki-article on AGEs points out. AGEs are everywhere in our food, and made in our body by all cells. Although browning reactions when cooking food that contains animal products are a particularly rich source of AGEs, vegetarians have a higher concentration of them in their body than non-vegetarians. Interestingly, higher molecular weight AGEs are not metabolised by the body, so are a kind of "empty calories", like soluble fibre, etc.

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Re: Obesogens

Post by shpalman » Fri Dec 15, 2023 4:25 pm

Nature reviews gastroenterology & hepatology heralds A new era in obesity management but it's paywalled.

https://doi.org/10.1038/s41575-023-00887-9
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Re: Obesogens

Post by shpalman » Mon May 13, 2024 4:51 pm

shpalman wrote:
Mon May 13, 2024 3:35 pm
Why do otherwise respected youtubers go anywhere near him? https://youtu.be/gU2YzX7xv4w
I'll cross post here because Johann Hari is really really trying to stir up a scary controversy about these weight loss drugs while admitting it really worked for him and lots of other people and he wants to keep taking it.

He also repeats the reading-comprehension-failure regarding Jay Rayner about 24 minutes in.
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Re: Obesogens

Post by Tessa K » Mon May 13, 2024 5:31 pm

shpalman wrote:
Mon May 13, 2024 4:51 pm
shpalman wrote:
Mon May 13, 2024 3:35 pm
Why do otherwise respected youtubers go anywhere near him? https://youtu.be/gU2YzX7xv4w
I'll cross post here because Johann Hari is really really trying to stir up a scary controversy about these weight loss drugs while admitting it really worked for him and lots of other people and he wants to keep taking it.

He also repeats the reading-comprehension-failure regarding Jay Rayner about 24 minutes in.
I feel the same about smoking.

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Re: Obesogens

Post by shpalman » Tue May 14, 2024 11:11 am

Tessa K wrote:
Mon May 13, 2024 5:31 pm
shpalman wrote:
Mon May 13, 2024 4:51 pm
shpalman wrote:
Mon May 13, 2024 3:35 pm
Why do otherwise respected youtubers go anywhere near him? https://youtu.be/gU2YzX7xv4w
I'll cross post here because Johann Hari is really really trying to stir up a scary controversy about these weight loss drugs while admitting it really worked for him and lots of other people and he wants to keep taking it.

He also repeats the reading-comprehension-failure regarding Jay Rayner about 24 minutes in.
I feel the same about smoking.
That smoking is trying to stir up a controversy about GLP-1 receptor agonists?
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Re: Obesogens

Post by shpalman » Sun May 19, 2024 6:42 pm

Results of a four year trial of semaglutide https://www.iflscience.com/weight-loss- ... -too-74263

Positive anecdotes in the comments on the Facebook post too https://www.facebook.com/share/WG5PoSY2hzYWn7E6/
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Re: Obesogens

Post by shpalman » Wed Jun 05, 2024 10:33 pm

Scientists are apparently finding that anti-obesity medicines can also help many other diseases I don't know it's paywalled, just as science is trying to be more open-access.
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Re: Obesogens

Post by shpalman » Tue Jun 18, 2024 9:58 am

Dr Layne Norton's favourite diet hacks

He also has a much better take on weight loss drugs than Johann Hari did.

His tl;dr in the rest of it is "eat more fibre".
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Re: Obesogens

Post by discovolante » Tue Jun 18, 2024 10:05 am

If you're going to link to YouTube could you say so?
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Re: Obesogens

Post by shpalman » Tue Jun 18, 2024 5:45 pm

Sorry.

These are links to a two-hour youtube video of Chris Williamson interviewing Dr. Layne Norton. I watched all of it, you don't have to, but it's actually interesting even if you're not a powerlifter.

I've also fixed the second link so it goes to the relevant bit of the clip this time.
shpalman wrote:
Tue Jun 18, 2024 9:58 am
Dr. Layne Norton's favourite diet hacks

He also has a much better take on weight loss drugs than Johann Hari did.

His tl;dr in the rest of it is "eat more fibre".
This was the same guy unfortunately interviewing Johann Hari:
shpalman wrote:
Mon May 13, 2024 3:35 pm
Why do otherwise respected youtubers go anywhere near him? https://youtu.be/gU2YzX7xv4w
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