Obesogens

[dyqik]

Visible six packs yet?

It's more about 4-packs around here.

[shpalman]

works though

The report concluded that administering semaglutide once a week gave “historically unprecedented” results, and brought about “clinically meaningful improvements”.

“These results underscore the high degree of clinical effectiveness of semaglutide in adolescents with obesity.”

Reducing BMI below the obesity threshold in adolescents treated with once-weekly subcutaneous semaglutide 2.4 mg

Semaglutide was highly effective in reducing BMI category. While on treatment, most trial participants' BMI improved by at least one category, and >40% reached a category below the obesity threshold.

[shpalman]

The weight-loss jab Wegovy can reduce the risk of major cardiovascular events by 20% in people who are overweight or obese.

The results of the study were shared in a press release by Novo Nordisk rather than in a peer-reviewed research paper, meaning detail was limited – including to what extent the findings could be down to the direct effects of Wegovy, or indirect effects as a result of weight loss.

Still, it's good that the weight loss drug has a benefit concerning the poor health outcomes of being overweight and obese, rather than only reducing weight.

[Tessa K]

The weight-loss jab Wegovy can reduce the risk of major cardiovascular events by 20% in people who are overweight or obese.

The results of the study were shared in a press release by Novo Nordisk rather than in a peer-reviewed research paper, meaning detail was limited – including to what extent the findings could be down to the direct effects of Wegovy, or indirect effects as a result of weight loss.

Still, it's good that the weight loss drug has a benefit concerning the poor health outcomes of being overweight and obese, rather than only reducing weight.

I listened to an Inside Health pod about this (BBC). It only works as long as the person keeps having it otherwise the weight comes back in almost everyone. The longterm effects are not yet known and it's expensive. It would be good eg for someone who needs to lose weight for surgery

[RoMo]

I listened to an Inside Health pod about this (BBC). It only works as long as the person keeps having it otherwise the weight comes back in almost everyone. The longterm effects are not yet known and it's expensive. It would be good eg for someone who needs to lose weight for surgery

Interesting article from Yoni Freedhoff here about semaglutide. Point 1 is that yes, if you stop taking it the weight will return, that's how treatment for chronic conditions work and no-one seems to mind for anything other than weight.

[Tessa K]

I listened to an Inside Health pod about this (BBC). It only works as long as the person keeps having it otherwise the weight comes back in almost everyone. The longterm effects are not yet known and it's expensive. It would be good eg for someone who needs to lose weight for surgery

Interesting article from Yoni Freedhoff here about semaglutide. Point 1 is that yes, if you stop taking it the weight will return, that's how treatment for chronic conditions work and no-one seems to mind for anything other than weight.

Partly because there's a moral judgment about obesity. Why should tax payer money be spent on something you should do for yourself?

[Martin_B]

I listened to an Inside Health pod about this (BBC). It only works as long as the person keeps having it otherwise the weight comes back in almost everyone. The longterm effects are not yet known and it's expensive. It would be good eg for someone who needs to lose weight for surgery

Interesting article from Yoni Freedhoff here about semaglutide. Point 1 is that yes, if you stop taking it the weight will return, that's how treatment for chronic conditions work and no-one seems to mind for anything other than weight.

[Anecdata] I was taking semaglutide and it led to me gaining weight. The side-effects of chronic indigestion (and low-grade diarrhea) led to a reduction in exercise and an increase in food uptake to combat the acid reflux. I've come off it and have started losing weight again! [/Anecdata]

[shpalman]

There's some more anecdata at https://www.washingtonpost.com/health/2 ... y-ozempic/

But we do know what the long-term effects of obesity and/or type II diabetes are.

[shpalman]

New peer reviewed Max Planck Institute study on GLP-1 agonist Liraglutide published today indicates that the weight loss drug Improves associative learning.

[shpalman]

Demand for weight-loss drugs Ozempic/Wegovy is so large that the government of Denmark (where drugmaker Novo Nordisk is from) now has to publish GDP data excluding it

[shpalman]

get more muscle

[shpalman]

Food which makes you eat more https://elifesciences.org/articles/82446

I found this via a local news website which managed to link directly to the paper, unlike the self-important both-sides morons at places like the BBC or the Guardian.

[Tessa K]

Food which makes you eat more https://elifesciences.org/articles/82446

I found this via a local news website which managed to link directly to the paper, unlike the self-important both-sides morons at places like the BBC or the Guardian.

Can you give some examples of foods for non science people? The abstract mentioned baking but is that all?

[IvanV]

Food which makes you eat more https://elifesciences.org/articles/82446

I found this via a local news website which managed to link directly to the paper, unlike the self-important both-sides morons at places like the BBC or the Guardian.

Can you give some examples of foods for non science people? The abstract mentioned baking but is that all?

This article refers to AGEs resulting from the Maillard reaction, which is the browning reaction that occurs in certain kinds of cooking. Whether its frying, baking, roasting, whether of pastry products, meat, potatoes, onions, veg, if it browned in cooking, that was the Maillard reaction, We all know that browning in cooking makes food tasty. It's why so many of us love barbecues, chips, the crust on bread, things with browned cheesy toppings, things cooked in breadcrumbs, etc.

This article makes the unsurprising connection that eating such tasty food encourages us to eat more than eating bland food. That tastes very nice, I'll have another one please.

On the more general point of whether AGEs are good for you or bad for you, which all Mail-readers will wish to know, they can be put in both columns, as the wiki-article on AGEs points out. AGEs are everywhere in our food, and made in our body by all cells. Although browning reactions when cooking food that contains animal products are a particularly rich source of AGEs, vegetarians have a higher concentration of them in their body than non-vegetarians. Interestingly, higher molecular weight AGEs are not metabolised by the body, so are a kind of "empty calories", like soluble fibre, etc.

[shpalman]

Nature reviews gastroenterology & hepatology heralds A new era in obesity management but it's paywalled.

https://doi.org/10.1038/s41575-023-00887-9

[shpalman]

Why do otherwise respected youtubers go anywhere near him? https://youtu.be/gU2YzX7xv4w

I'll cross post here because Johann Hari is really really trying to stir up a scary controversy about these weight loss drugs while admitting it really worked for him and lots of other people and he wants to keep taking it.

He also repeats the reading-comprehension-failure regarding Jay Rayner about 24 minutes in.

[Tessa K]

Why do otherwise respected youtubers go anywhere near him? https://youtu.be/gU2YzX7xv4w

I'll cross post here because Johann Hari is really really trying to stir up a scary controversy about these weight loss drugs while admitting it really worked for him and lots of other people and he wants to keep taking it.

He also repeats the reading-comprehension-failure regarding Jay Rayner about 24 minutes in.

I feel the same about smoking.

[shpalman]

Why do otherwise respected youtubers go anywhere near him? https://youtu.be/gU2YzX7xv4w

I'll cross post here because Johann Hari is really really trying to stir up a scary controversy about these weight loss drugs while admitting it really worked for him and lots of other people and he wants to keep taking it.

He also repeats the reading-comprehension-failure regarding Jay Rayner about 24 minutes in.

I feel the same about smoking.

That smoking is trying to stir up a controversy about GLP-1 receptor agonists?

[shpalman]

Results of a four year trial of semaglutide https://www.iflscience.com/weight-loss- ... -too-74263

Positive anecdotes in the comments on the Facebook post too https://www.facebook.com/share/WG5PoSY2hzYWn7E6/

[shpalman]

Scientists are apparently finding that anti-obesity medicines can also help many other diseases I don't know it's paywalled, just as science is trying to be more open-access.

[shpalman]

Dr Layne Norton's favourite diet hacks

He also has a much better take on weight loss drugs than Johann Hari did.

His tl;dr in the rest of it is "eat more fibre".

[discovolante]

If you're going to link to YouTube could you say so?

[shpalman]

Sorry.

These are links to a two-hour youtube video of Chris Williamson interviewing Dr. Layne Norton. I watched all of it, you don't have to, but it's actually interesting even if you're not a powerlifter.

I've also fixed the second link so it goes to the relevant bit of the clip this time.

Dr. Layne Norton's favourite diet hacks

He also has a much better take on weight loss drugs than Johann Hari did.

His tl;dr in the rest of it is "eat more fibre".

This was the same guy unfortunately interviewing Johann Hari:

Why do otherwise respected youtubers go anywhere near him? https://youtu.be/gU2YzX7xv4w