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Obesogens
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Re: Obesogens
Reducing BMI below the obesity threshold in adolescents treated with once-weekly subcutaneous semaglutide 2.4 mgshpalman wrote: ↑Thu May 18, 2023 6:45 amworks though
The report concluded that administering semaglutide once a week gave “historically unprecedented” results, and brought about “clinically meaningful improvements”.
“These results underscore the high degree of clinical effectiveness of semaglutide in adolescents with obesity.”
Semaglutide was highly effective in reducing BMI category. While on treatment, most trial participants' BMI improved by at least one category, and >40% reached a category below the obesity threshold.
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Re: Obesogens
The weight-loss jab Wegovy can reduce the risk of major cardiovascular events by 20% in people who are overweight or obese.
Still, it's good that the weight loss drug has a benefit concerning the poor health outcomes of being overweight and obese, rather than only reducing weight.The results of the study were shared in a press release by Novo Nordisk rather than in a peer-reviewed research paper, meaning detail was limited – including to what extent the findings could be down to the direct effects of Wegovy, or indirect effects as a result of weight loss.
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Re: Obesogens
I listened to an Inside Health pod about this (BBC). It only works as long as the person keeps having it otherwise the weight comes back in almost everyone. The longterm effects are not yet known and it's expensive. It would be good eg for someone who needs to lose weight for surgeryshpalman wrote: ↑Thu Aug 10, 2023 10:07 amThe weight-loss jab Wegovy can reduce the risk of major cardiovascular events by 20% in people who are overweight or obese.
Still, it's good that the weight loss drug has a benefit concerning the poor health outcomes of being overweight and obese, rather than only reducing weight.The results of the study were shared in a press release by Novo Nordisk rather than in a peer-reviewed research paper, meaning detail was limited – including to what extent the findings could be down to the direct effects of Wegovy, or indirect effects as a result of weight loss.
Re: Obesogens
Interesting article from Yoni Freedhoff here about semaglutide. Point 1 is that yes, if you stop taking it the weight will return, that's how treatment for chronic conditions work and no-one seems to mind for anything other than weight.Tessa K wrote: ↑Thu Aug 10, 2023 12:42 pm
I listened to an Inside Health pod about this (BBC). It only works as long as the person keeps having it otherwise the weight comes back in almost everyone. The longterm effects are not yet known and it's expensive. It would be good eg for someone who needs to lose weight for surgery
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Re: Obesogens
Partly because there's a moral judgment about obesity. Why should tax payer money be spent on something you should do for yourself?RoMo wrote: ↑Fri Aug 11, 2023 5:34 amInteresting article from Yoni Freedhoff here about semaglutide. Point 1 is that yes, if you stop taking it the weight will return, that's how treatment for chronic conditions work and no-one seems to mind for anything other than weight.Tessa K wrote: ↑Thu Aug 10, 2023 12:42 pm
I listened to an Inside Health pod about this (BBC). It only works as long as the person keeps having it otherwise the weight comes back in almost everyone. The longterm effects are not yet known and it's expensive. It would be good eg for someone who needs to lose weight for surgery
Re: Obesogens
[Anecdata] I was taking semaglutide and it led to me gaining weight. The side-effects of chronic indigestion (and low-grade diarrhea) led to a reduction in exercise and an increase in food uptake to combat the acid reflux. I've come off it and have started losing weight again! [/Anecdata]RoMo wrote: ↑Fri Aug 11, 2023 5:34 amInteresting article from Yoni Freedhoff here about semaglutide. Point 1 is that yes, if you stop taking it the weight will return, that's how treatment for chronic conditions work and no-one seems to mind for anything other than weight.Tessa K wrote: ↑Thu Aug 10, 2023 12:42 pm
I listened to an Inside Health pod about this (BBC). It only works as long as the person keeps having it otherwise the weight comes back in almost everyone. The longterm effects are not yet known and it's expensive. It would be good eg for someone who needs to lose weight for surgery
"My interest is in the future, because I'm going to spend the rest of my life there"
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Re: Obesogens
There's some more anecdata at https://www.washingtonpost.com/health/2 ... y-ozempic/
But we do know what the long-term effects of obesity and/or type II diabetes are.
But we do know what the long-term effects of obesity and/or type II diabetes are.
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Re: Obesogens
having that swing is a necessary but not sufficient condition for it meaning a thing
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Re: Obesogens
having that swing is a necessary but not sufficient condition for it meaning a thing
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Re: Obesogens
having that swing is a necessary but not sufficient condition for it meaning a thing
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Re: Obesogens
Food which makes you eat more https://elifesciences.org/articles/82446
I found this via a local news website which managed to link directly to the paper, unlike the self-important both-sides morons at places like the BBC or the Guardian.
I found this via a local news website which managed to link directly to the paper, unlike the self-important both-sides morons at places like the BBC or the Guardian.
having that swing is a necessary but not sufficient condition for it meaning a thing
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Re: Obesogens
Can you give some examples of foods for non science people? The abstract mentioned baking but is that all?shpalman wrote: ↑Thu Oct 19, 2023 9:51 amFood which makes you eat more https://elifesciences.org/articles/82446
I found this via a local news website which managed to link directly to the paper, unlike the self-important both-sides morons at places like the BBC or the Guardian.
Re: Obesogens
This article refers to AGEs resulting from the Maillard reaction, which is the browning reaction that occurs in certain kinds of cooking. Whether its frying, baking, roasting, whether of pastry products, meat, potatoes, onions, veg, if it browned in cooking, that was the Maillard reaction, We all know that browning in cooking makes food tasty. It's why so many of us love barbecues, chips, the crust on bread, things with browned cheesy toppings, things cooked in breadcrumbs, etc.Tessa K wrote: ↑Thu Oct 19, 2023 10:48 amCan you give some examples of foods for non science people? The abstract mentioned baking but is that all?shpalman wrote: ↑Thu Oct 19, 2023 9:51 amFood which makes you eat more https://elifesciences.org/articles/82446
I found this via a local news website which managed to link directly to the paper, unlike the self-important both-sides morons at places like the BBC or the Guardian.
This article makes the unsurprising connection that eating such tasty food encourages us to eat more than eating bland food. That tastes very nice, I'll have another one please.
On the more general point of whether AGEs are good for you or bad for you, which all Mail-readers will wish to know, they can be put in both columns, as the wiki-article on AGEs points out. AGEs are everywhere in our food, and made in our body by all cells. Although browning reactions when cooking food that contains animal products are a particularly rich source of AGEs, vegetarians have a higher concentration of them in their body than non-vegetarians. Interestingly, higher molecular weight AGEs are not metabolised by the body, so are a kind of "empty calories", like soluble fibre, etc.
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Re: Obesogens
Nature reviews gastroenterology & hepatology heralds A new era in obesity management but it's paywalled.
https://doi.org/10.1038/s41575-023-00887-9
https://doi.org/10.1038/s41575-023-00887-9
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Re: Obesogens
I'll cross post here because Johann Hari is really really trying to stir up a scary controversy about these weight loss drugs while admitting it really worked for him and lots of other people and he wants to keep taking it.shpalman wrote: ↑Mon May 13, 2024 3:35 pmWhy do otherwise respected youtubers go anywhere near him? https://youtu.be/gU2YzX7xv4w
He also repeats the reading-comprehension-failure regarding Jay Rayner about 24 minutes in.
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- Tessa K
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Re: Obesogens
I feel the same about smoking.shpalman wrote: ↑Mon May 13, 2024 4:51 pmI'll cross post here because Johann Hari is really really trying to stir up a scary controversy about these weight loss drugs while admitting it really worked for him and lots of other people and he wants to keep taking it.shpalman wrote: ↑Mon May 13, 2024 3:35 pmWhy do otherwise respected youtubers go anywhere near him? https://youtu.be/gU2YzX7xv4w
He also repeats the reading-comprehension-failure regarding Jay Rayner about 24 minutes in.
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Re: Obesogens
That smoking is trying to stir up a controversy about GLP-1 receptor agonists?Tessa K wrote: ↑Mon May 13, 2024 5:31 pmI feel the same about smoking.shpalman wrote: ↑Mon May 13, 2024 4:51 pmI'll cross post here because Johann Hari is really really trying to stir up a scary controversy about these weight loss drugs while admitting it really worked for him and lots of other people and he wants to keep taking it.shpalman wrote: ↑Mon May 13, 2024 3:35 pmWhy do otherwise respected youtubers go anywhere near him? https://youtu.be/gU2YzX7xv4w
He also repeats the reading-comprehension-failure regarding Jay Rayner about 24 minutes in.
having that swing is a necessary but not sufficient condition for it meaning a thing
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- shpalman
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Re: Obesogens
Results of a four year trial of semaglutide https://www.iflscience.com/weight-loss- ... -too-74263
Positive anecdotes in the comments on the Facebook post too https://www.facebook.com/share/WG5PoSY2hzYWn7E6/
Positive anecdotes in the comments on the Facebook post too https://www.facebook.com/share/WG5PoSY2hzYWn7E6/
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Re: Obesogens
Scientists are apparently finding that anti-obesity medicines can also help many other diseases I don't know it's paywalled, just as science is trying to be more open-access.
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Re: Obesogens
Dr Layne Norton's favourite diet hacks
He also has a much better take on weight loss drugs than Johann Hari did.
His tl;dr in the rest of it is "eat more fibre".
He also has a much better take on weight loss drugs than Johann Hari did.
His tl;dr in the rest of it is "eat more fibre".
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Re: Obesogens
If you're going to link to YouTube could you say so?
To defy the laws of tradition is a crusade only of the brave.
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Re: Obesogens
Sorry.
These are links to a two-hour youtube video of Chris Williamson interviewing Dr. Layne Norton. I watched all of it, you don't have to, but it's actually interesting even if you're not a powerlifter.
I've also fixed the second link so it goes to the relevant bit of the clip this time.
These are links to a two-hour youtube video of Chris Williamson interviewing Dr. Layne Norton. I watched all of it, you don't have to, but it's actually interesting even if you're not a powerlifter.
I've also fixed the second link so it goes to the relevant bit of the clip this time.
This was the same guy unfortunately interviewing Johann Hari:shpalman wrote: ↑Tue Jun 18, 2024 9:58 amDr. Layne Norton's favourite diet hacks
He also has a much better take on weight loss drugs than Johann Hari did.
His tl;dr in the rest of it is "eat more fibre".
shpalman wrote: ↑Mon May 13, 2024 3:35 pmWhy do otherwise respected youtubers go anywhere near him? https://youtu.be/gU2YzX7xv4w
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