Obesogens

[dyqik]

Visible six packs yet?

It's more about 4-packs around here.

[shpalman]

works though

The report concluded that administering semaglutide once a week gave “historically unprecedented” results, and brought about “clinically meaningful improvements”.

“These results underscore the high degree of clinical effectiveness of semaglutide in adolescents with obesity.”

Reducing BMI below the obesity threshold in adolescents treated with once-weekly subcutaneous semaglutide 2.4 mg

Semaglutide was highly effective in reducing BMI category. While on treatment, most trial participants' BMI improved by at least one category, and >40% reached a category below the obesity threshold.

[shpalman]

The weight-loss jab Wegovy can reduce the risk of major cardiovascular events by 20% in people who are overweight or obese.

The results of the study were shared in a press release by Novo Nordisk rather than in a peer-reviewed research paper, meaning detail was limited – including to what extent the findings could be down to the direct effects of Wegovy, or indirect effects as a result of weight loss.

Still, it's good that the weight loss drug has a benefit concerning the poor health outcomes of being overweight and obese, rather than only reducing weight.

[Tessa K]

The weight-loss jab Wegovy can reduce the risk of major cardiovascular events by 20% in people who are overweight or obese.

The results of the study were shared in a press release by Novo Nordisk rather than in a peer-reviewed research paper, meaning detail was limited – including to what extent the findings could be down to the direct effects of Wegovy, or indirect effects as a result of weight loss.

Still, it's good that the weight loss drug has a benefit concerning the poor health outcomes of being overweight and obese, rather than only reducing weight.

I listened to an Inside Health pod about this (BBC). It only works as long as the person keeps having it otherwise the weight comes back in almost everyone. The longterm effects are not yet known and it's expensive. It would be good eg for someone who needs to lose weight for surgery

[RoMo]

I listened to an Inside Health pod about this (BBC). It only works as long as the person keeps having it otherwise the weight comes back in almost everyone. The longterm effects are not yet known and it's expensive. It would be good eg for someone who needs to lose weight for surgery

Interesting article from Yoni Freedhoff here about semaglutide. Point 1 is that yes, if you stop taking it the weight will return, that's how treatment for chronic conditions work and no-one seems to mind for anything other than weight.

[Tessa K]

I listened to an Inside Health pod about this (BBC). It only works as long as the person keeps having it otherwise the weight comes back in almost everyone. The longterm effects are not yet known and it's expensive. It would be good eg for someone who needs to lose weight for surgery

Interesting article from Yoni Freedhoff here about semaglutide. Point 1 is that yes, if you stop taking it the weight will return, that's how treatment for chronic conditions work and no-one seems to mind for anything other than weight.

Partly because there's a moral judgment about obesity. Why should tax payer money be spent on something you should do for yourself?

[Martin_B]

I listened to an Inside Health pod about this (BBC). It only works as long as the person keeps having it otherwise the weight comes back in almost everyone. The longterm effects are not yet known and it's expensive. It would be good eg for someone who needs to lose weight for surgery

Interesting article from Yoni Freedhoff here about semaglutide. Point 1 is that yes, if you stop taking it the weight will return, that's how treatment for chronic conditions work and no-one seems to mind for anything other than weight.

[Anecdata] I was taking semaglutide and it led to me gaining weight. The side-effects of chronic indigestion (and low-grade diarrhea) led to a reduction in exercise and an increase in food uptake to combat the acid reflux. I've come off it and have started losing weight again! [/Anecdata]

[shpalman]

There's some more anecdata at https://www.washingtonpost.com/health/2 ... y-ozempic/

But we do know what the long-term effects of obesity and/or type II diabetes are.

[shpalman]

New peer reviewed Max Planck Institute study on GLP-1 agonist Liraglutide published today indicates that the weight loss drug Improves associative learning.

[shpalman]

Demand for weight-loss drugs Ozempic/Wegovy is so large that the government of Denmark (where drugmaker Novo Nordisk is from) now has to publish GDP data excluding it