Re: Obesogens
Posted: Mon Jul 24, 2023 2:35 pm
Reducing BMI below the obesity threshold in adolescents treated with once-weekly subcutaneous semaglutide 2.4 mgshpalman wrote: ↑Thu May 18, 2023 6:45 amworks though
The report concluded that administering semaglutide once a week gave “historically unprecedented” results, and brought about “clinically meaningful improvements”.
“These results underscore the high degree of clinical effectiveness of semaglutide in adolescents with obesity.”
Semaglutide was highly effective in reducing BMI category. While on treatment, most trial participants' BMI improved by at least one category, and >40% reached a category below the obesity threshold.
Still, it's good that the weight loss drug has a benefit concerning the poor health outcomes of being overweight and obese, rather than only reducing weight.The results of the study were shared in a press release by Novo Nordisk rather than in a peer-reviewed research paper, meaning detail was limited – including to what extent the findings could be down to the direct effects of Wegovy, or indirect effects as a result of weight loss.
I listened to an Inside Health pod about this (BBC). It only works as long as the person keeps having it otherwise the weight comes back in almost everyone. The longterm effects are not yet known and it's expensive. It would be good eg for someone who needs to lose weight for surgeryshpalman wrote: ↑Thu Aug 10, 2023 10:07 amThe weight-loss jab Wegovy can reduce the risk of major cardiovascular events by 20% in people who are overweight or obese.
Still, it's good that the weight loss drug has a benefit concerning the poor health outcomes of being overweight and obese, rather than only reducing weight.The results of the study were shared in a press release by Novo Nordisk rather than in a peer-reviewed research paper, meaning detail was limited – including to what extent the findings could be down to the direct effects of Wegovy, or indirect effects as a result of weight loss.
Interesting article from Yoni Freedhoff here about semaglutide. Point 1 is that yes, if you stop taking it the weight will return, that's how treatment for chronic conditions work and no-one seems to mind for anything other than weight.Tessa K wrote: ↑Thu Aug 10, 2023 12:42 pm
I listened to an Inside Health pod about this (BBC). It only works as long as the person keeps having it otherwise the weight comes back in almost everyone. The longterm effects are not yet known and it's expensive. It would be good eg for someone who needs to lose weight for surgery
Partly because there's a moral judgment about obesity. Why should tax payer money be spent on something you should do for yourself?RoMo wrote: ↑Fri Aug 11, 2023 5:34 amInteresting article from Yoni Freedhoff here about semaglutide. Point 1 is that yes, if you stop taking it the weight will return, that's how treatment for chronic conditions work and no-one seems to mind for anything other than weight.Tessa K wrote: ↑Thu Aug 10, 2023 12:42 pm
I listened to an Inside Health pod about this (BBC). It only works as long as the person keeps having it otherwise the weight comes back in almost everyone. The longterm effects are not yet known and it's expensive. It would be good eg for someone who needs to lose weight for surgery
[Anecdata] I was taking semaglutide and it led to me gaining weight. The side-effects of chronic indigestion (and low-grade diarrhea) led to a reduction in exercise and an increase in food uptake to combat the acid reflux. I've come off it and have started losing weight again! [/Anecdata]RoMo wrote: ↑Fri Aug 11, 2023 5:34 amInteresting article from Yoni Freedhoff here about semaglutide. Point 1 is that yes, if you stop taking it the weight will return, that's how treatment for chronic conditions work and no-one seems to mind for anything other than weight.Tessa K wrote: ↑Thu Aug 10, 2023 12:42 pm
I listened to an Inside Health pod about this (BBC). It only works as long as the person keeps having it otherwise the weight comes back in almost everyone. The longterm effects are not yet known and it's expensive. It would be good eg for someone who needs to lose weight for surgery
Can you give some examples of foods for non science people? The abstract mentioned baking but is that all?shpalman wrote: ↑Thu Oct 19, 2023 9:51 amFood which makes you eat more https://elifesciences.org/articles/82446
I found this via a local news website which managed to link directly to the paper, unlike the self-important both-sides morons at places like the BBC or the Guardian.
This article refers to AGEs resulting from the Maillard reaction, which is the browning reaction that occurs in certain kinds of cooking. Whether its frying, baking, roasting, whether of pastry products, meat, potatoes, onions, veg, if it browned in cooking, that was the Maillard reaction, We all know that browning in cooking makes food tasty. It's why so many of us love barbecues, chips, the crust on bread, things with browned cheesy toppings, things cooked in breadcrumbs, etc.Tessa K wrote: ↑Thu Oct 19, 2023 10:48 amCan you give some examples of foods for non science people? The abstract mentioned baking but is that all?shpalman wrote: ↑Thu Oct 19, 2023 9:51 amFood which makes you eat more https://elifesciences.org/articles/82446
I found this via a local news website which managed to link directly to the paper, unlike the self-important both-sides morons at places like the BBC or the Guardian.
I'll cross post here because Johann Hari is really really trying to stir up a scary controversy about these weight loss drugs while admitting it really worked for him and lots of other people and he wants to keep taking it.shpalman wrote: ↑Mon May 13, 2024 3:35 pmWhy do otherwise respected youtubers go anywhere near him? https://youtu.be/gU2YzX7xv4w
I feel the same about smoking.shpalman wrote: ↑Mon May 13, 2024 4:51 pmI'll cross post here because Johann Hari is really really trying to stir up a scary controversy about these weight loss drugs while admitting it really worked for him and lots of other people and he wants to keep taking it.shpalman wrote: ↑Mon May 13, 2024 3:35 pmWhy do otherwise respected youtubers go anywhere near him? https://youtu.be/gU2YzX7xv4w
He also repeats the reading-comprehension-failure regarding Jay Rayner about 24 minutes in.
That smoking is trying to stir up a controversy about GLP-1 receptor agonists?Tessa K wrote: ↑Mon May 13, 2024 5:31 pmI feel the same about smoking.shpalman wrote: ↑Mon May 13, 2024 4:51 pmI'll cross post here because Johann Hari is really really trying to stir up a scary controversy about these weight loss drugs while admitting it really worked for him and lots of other people and he wants to keep taking it.shpalman wrote: ↑Mon May 13, 2024 3:35 pmWhy do otherwise respected youtubers go anywhere near him? https://youtu.be/gU2YzX7xv4w
He also repeats the reading-comprehension-failure regarding Jay Rayner about 24 minutes in.
This was the same guy unfortunately interviewing Johann Hari:shpalman wrote: ↑Tue Jun 18, 2024 9:58 amDr. Layne Norton's favourite diet hacks
He also has a much better take on weight loss drugs than Johann Hari did.
His tl;dr in the rest of it is "eat more fibre".
shpalman wrote: ↑Mon May 13, 2024 3:35 pmWhy do otherwise respected youtubers go anywhere near him? https://youtu.be/gU2YzX7xv4w