Is it all over for the AstraZeneca vaccine?

[sTeamTraen]

Spain's official figure for doses of AZ delivered fell again this week. It's now down to 9,979,000, which is 408,800 below the number in mid-July. I presume they are working out who still needs a second AZ dose more accurately, and sending the rest elsewhere.

Spain's official deliveries of the Janssen (Johnson & Johnson) vaccine peaked at 2,648,335 on 9 August. Today they stand at 2,400,410.

Maybe the thread title should be changed to "Is it all over for adenovirus vector vaccines?"

[shpalman]

Seems like Italy gave away (or otherwise got rid of) about half a million Astra Zeneca doses today.

Maybe to support countries less fortunate than ourselves e.g. the UK and its drive to give third doses to anyone vulnerable or in a poor state of health i.e. the entire over-50s population.

[shpalman]

it would be “completely unfair” to suggest the AstraZeneca vaccine was not as good as once thought.

AstraZeneca has played a phenomenal role in protecting our country.

The difference now is... this variant, and different types of vaccines will react in different ways. But whether it’s AstraZeneca you had for your first two doses or its Pfizer or Moderna, you still need a booster shot to be protected against this new variant.

But not a booster of AstraZeneca of course, because it's a bit sh.t.

[Herainestold]

it would be “completely unfair” to suggest the AstraZeneca vaccine was not as good as once thought.

AstraZeneca has played a phenomenal role in protecting our country.

The difference now is... this variant, and different types of vaccines will react in different ways. But whether it’s AstraZeneca you had for your first two doses or its Pfizer or Moderna, you still need a booster shot to be protected against this new variant.

But not a booster of AstraZeneca of course, because it's a bit sh.t.

Not as sh.t as Janssen.

[bob sterman]

it would be “completely unfair” to suggest the AstraZeneca vaccine was not as good as once thought.

AstraZeneca has played a phenomenal role in protecting our country.

The difference now is... this variant, and different types of vaccines will react in different ways. But whether it’s AstraZeneca you had for your first two doses or its Pfizer or Moderna, you still need a booster shot to be protected against this new variant.

But not a booster of AstraZeneca of course, because it's a bit sh.t.

Not as sh.t as Janssen.

And both still better than GSK!

[Herainestold]

A table that ranks covid vaccines, from a nature paper

https://www.nature.com/articles/s41598- ... z/tables/2

As you might expect Pfizer at the top, Janssen and AZ at the bottom.

All moot w.r.t. Omicron.

[WFJ]

A table that ranks covid vaccines, from a nature Scientific Reports paper

https://www.nature.com/articles/s41598- ... z/tables/2

As you might expect Pfizer at the top, Janssen and AZ at the bottom.

All moot w.r.t. Omicron.

FIFY—not that that necessarily means there's anything wrong with it.

[bob sterman]

A table that ranks covid vaccines, from a nature paper

https://www.nature.com/articles/s41598- ... z/tables/2

As you might expect Pfizer at the top, Janssen and AZ at the bottom.

Although worth noting the metric...

"P-score represents the probability of each intervention is being better than all competing interventions, derived from network point estimates and standard errors.

So the scale is 0 (worst) to 1 (best). And a vaccine scoring close to 0 doesn't have to be sh*t - just not quite as good as the others.

[Herainestold]

A table that ranks covid vaccines, from a nature Scientific Reports paper

https://www.nature.com/articles/s41598- ... z/tables/2

As you might expect Pfizer at the top, Janssen and AZ at the bottom.

All moot w.r.t. Omicron.

FIFY—not that that necessarily means there's anything wrong with it.

Point taken.

[Millennie Al]

A table that ranks covid vaccines, from a nature paper

https://www.nature.com/articles/s41598- ... z/tables/2

As you might expect Pfizer at the top, Janssen and AZ at the bottom.

Although worth noting the metric...

"P-score represents the probability of each intervention is being better than all competing interventions, derived from network point estimates and standard errors.

Also worth noting that the first column with all the figures is for prevention of symptomatic disease. We don't care about that. There are two things we care about:

1. Prevention of any disease
2. Prevention of serious (needs hospitalisation) disease

[Herainestold]

A table that ranks covid vaccines, from a nature paper

https://www.nature.com/articles/s41598- ... z/tables/2

As you might expect Pfizer at the top, Janssen and AZ at the bottom.

Although worth noting the metric...

"P-score represents the probability of each intervention is being better than all competing interventions, derived from network point estimates and standard errors.

Also worth noting that the first column with all the figures is for prevention of symptomatic disease. We don't care about that. There are two things we care about:

1. Prevention of any disease
2. Prevention of serious (needs hospitalisation) disease

If we say prevention of any disease, that includes asymptomatic, and vaccine efficacy against any disease, after three or four months, is very low.
What we should really be caring about, serious outcomes. Hospitalization, critical care beds and death.

I posted that chart because I was curious how vaccines were ranked. It is all moot now, Omicron is among us.