Developing the Covid-19 vaccine

[EACLucifer]

Again with treatment not vaccine, but the WHO is trying a similar approach to the one they took with the recent Ebola outbreak.

Candidates are remdesivir, lopinavir and ritonavir; lopinavir and ritonavir plus interferon beta, and chloroquine.

[AMS]

I think some of the pharmas are also looking for monoclonal antibodies that block the virus from infecting cells. It's not tried and tested stuff, but people have looked at inhaler-style delivery routes. It will take longer than repurposing existing meds, though.

[Herainestold]

The Chinese military has been working on a vaccine.

“China’s announcement of a clinical trial came a little bit earlier than I had expected, even though I believe the first dose of the recombinant vaccine has already been injected into Chen’s body and some of her teammates,” Tao Lina, a Shanghai-based vaccine expert, said.

Tao was referring to photos that have been circulating on the social media platform WeChat that showed Chen being injected with a possible vaccine.
China developing 9 potential vaccines in global race for coronavirus cure
19 Mar 2020

Chen, 54 specialises in the development of recombinant vaccines – which use a harmless virus or bacterium to introduce the pathogen’s genetic material into the body to build up immunity – and has been credited with helping develop treatments during the 2014-16 Ebola outbreak.

She also developed a nasal spray to protect medical workers during the 2002-03 outbreak of severe acute respiratory syndrome (Sars).

The Chinese military has also been helping to tackle the medical emergency in Hubei, the province at the centre of the outbreak, with more than 10,000 personnel being deployed.

https://www.scmp.com/news/china/militar ... ce-develop

[shpalman]

one in six Britons displaying evidence of having arrived at a conclusion based on incorrect or biased information and/or faulty reasoning processes

[Woodchopper]

one in six Britons displaying evidence of having arrived at a conclusion based on incorrect or biased information and/or faulty reasoning processes

Actually it’s only 6% who stated that they definitely would not.
https://docs.cdn.yougov.com/5mkju0kxbj/ ... 002%29.pdf

Though another 10% probably would not. Hopefully they could be persuaded.

[Millennie Al]

one in six Britons displaying evidence of having arrived at a conclusion based on incorrect or biased information and/or faulty reasoning processes

That's hardly news given that the country voted for Brexit.

[shpalman]

The Oxford vaccine seems to work.

[snoozeofreason]

The Oxford vaccine seems to work.

But for some reason your link doesn't, even though it seems correct. Try copying

Code: Select all

https://www.thelancet.com/lancet/article/s0140-6736(20)31604-4

into the address bar of a browser

[shpalman]

STUPID f.cking c.nting BRACKETS IN DOIs coupled with phpBB being "helpful" that's why

[Gfamily]

STUPID f.cking c.nting BRACKETS IN DOIs coupled with phpBB being "helpful" that's why

I was going to say something similar, except it was more along the lines of
replace %28 by (
and replace %29 by )

[shpalman]

STUPID f.cking c.nting BRACKETS IN DOIs coupled with phpBB being "helpful" that's why

I was going to say something similar, except it was more along the lines of
replace %28 by (
and replace %29 by )

They were f.cking brackets when they left here.

[discovolante]

Can someone who is more knowledgeable than me explain how a vaccine would overcome the apparent fact that antibodies from infection don't seem to be lasting that long? Asks she who knows very little about vaccines despite 12 years hanging around here.

[Gfamily]

Can someone who is more knowledgeable than me explain how a vaccine would overcome the apparent fact that antibodies from infection don't seem to be lasting that long? Asks she who knows very little about vaccines despite 12 years hanging around here.

It's a good question, and I don't know if this helps
https://www.technologynetworks.com/immu ... ces-293550

tl:dr is that the vaccine causes not only an immediate creation of antibodies by B cells, but also the development of 'Memory B cells', which mean the body can make a much faster response to future infection

[sTeamTraen]

The vaccine is called "ChAdOx1 nCoV-19", which I presume is what happens when you let your 12-year-old son and his pals name it.

[basementer]

The vaccine is called "ChAdOx1 nCoV-19", which I presume is what happens when you let your 12-year-old son and his pals name it.

Looks like the name of Elon Musk's next child.

[discovolante]

Can someone who is more knowledgeable than me explain how a vaccine would overcome the apparent fact that antibodies from infection don't seem to be lasting that long? Asks she who knows very little about vaccines despite 12 years hanging around here.

It's a good question, and I don't know if this helps
https://www.technologynetworks.com/immu ... ces-293550

tl:dr is that the vaccine causes not only an immediate creation of antibodies by B cells, but also the development of 'Memory B cells', which mean the body can make a much faster response to future infection

Thank you, I'll have a read through that link later.

[Herainestold]

How will they decide who gets it, if and when it becomes available?

[sTeamTraen]

How will they decide who gets it, if and when it becomes available?

The UK government has pre-ordered 100 million doses. I presume it will go to Michael Gove and his family first, then healthcare workers, then be offered to people over 65 or those with other pre-existing conditions. Maybe also schoolteachers?

[Sciolus]

As LPM (I think) pointed out, it *should* go to superspreaders first, which will provide more protection to the vulnerable than vaccinating them directly by stamping out the spread. So I presume that would include healthcare/care home workers, teachers, public transport workers etc.

The interesting question is which countries get it first.

[JQH]

Those with the deepest pockets. Or one with a lunatic head of state sends its military in to snaffle the vaccine.

Today's script conference was a bit out there.

[jdc]

Can someone who is more knowledgeable than me explain how a vaccine would overcome the apparent fact that antibodies from infection don't seem to be lasting that long? Asks she who knows very little about vaccines despite 12 years hanging around here.

There seems to be a school of thought that we'll be needing revaccination.

Prof Sir John Bell, of the University of Oxford, said he thought it was unlikely that Covid-19 would ever be eliminated [...] "The vaccine is unlikely to have a durable effect that'll last for a very long time, so we're going to have to have a continual cycle of vaccinations, and then more disease, and more vaccinations and more disease."

[Millennie Al]

The vaccine is called "ChAdOx1 nCoV-19", which I presume is what happens when you let your 12-year-old son and his pals name it.

It uses a chimpanzee adenovirus developed at Oxford as a base. There are two of these, and it uses number 1. It combats a novel Coronavirus first seen in 2019. So, yes, naming may well have involved 12-year olds.

Some details at https://www.vaccitech.co.uk/technology/

[Woodchopper]

The vaccine is called "ChAdOx1 nCoV-19", which I presume is what happens when you let your 12-year-old son and his pals name it.

It uses a chimpanzee adenovirus developed at Oxford as a base. There are two of these, and it uses number 1. It combats a novel Coronavirus first seen in 2019. So, yes, naming may well have involved 12-year olds.

Some details at https://www.vaccitech.co.uk/technology/

Don’t tell the antivaxxers. As soon as they hear about humans being injected with a monkey virus they’ll go apeshit.

[headshot]

The vaccine is called "ChAdOx1 nCoV-19", which I presume is what happens when you let your 12-year-old son and his pals name it.

It uses a chimpanzee adenovirus developed at Oxford as a base. There are two of these, and it uses number 1. It combats a novel Coronavirus first seen in 2019. So, yes, naming may well have involved 12-year olds.

Some details at https://www.vaccitech.co.uk/technology/

Don’t tell the antivaxxers. As soon as they hear about humans being injected with a monkey virus they’ll go apeshit.

Do not rhesusitate?

[Gfamily]

Don’t tell the antivaxxers. As soon as they hear about humans being injected with a monkey virus they’ll go apeshit.

Do not rhesusitate?

Very good