Here's what I don't get

[warumich]

So both my gf and our son are on their second bout of Covid, first one was in October, both times son brought it home from school, so he tests positive first, then a couple of days later, his mum.

I keep testing negative though - I'm trying to be careful of course so I'm in the spare bedroom with the windows open and only talking to the others via WhatsApp or with a mask on through the doorway. But that's what she did too.

So, I kind of worry whether I don't swab correctly? Or am I naturally more resistant? Is that a thing? Did my gf secretly break the cuddle embargo? Or just lucky?

I just don't get it!

[bob sterman]

I just don't get it!

There's your answer!

[lpm]

Catch it now, while a 3rd jab is still strong, and it's quite likely for anyone to be asymptomatic and not register enough for a positive test.

My bet is you caught it both times, and almost certainly caught it this time as it's Omi, and you are missing out on valuable cuddles through over-caution.

[WFJ]

Maybe you're catching it first, but are asymptomatic, then you pass it on and have cleared it before they show symptoms.

[Gfamily]

Would pretending to have symptoms online let you book a PCR test? That's supposed to show whether you have had an infection for up to 90 days

[shpalman]

Or can you get antibody self-tests which distinguish between S and N proteins?

[warumich]

I just don't get it!

There's your answer!

To be honest this silly joke was half the reason I started the thread. But yea, I've actually also had a pcr test, and still negative.

Don't think I caught it first, both times there was a bit of an outbreak in my son's class, so pretty sure he got it from there first.

[Herainestold]

Maybe you are immune.

It is not impossible and the evidence points that way.

[Gfamily]

Given that appx 12% of common cold infections are caused by a Coronavirus, there was a hypothesis that this would provide immunity to Covid-19.

I've no idea what the current thinking is on this.

[Herainestold]

Given that appx 12% of common cold infections are caused by a Coronavirus, there was a hypothesis that this would provide immunity to Covid-19.

I've no idea what the current thinking is on this.

I think that's been debunked. Even Covid doesn't give immunity against Covid. (Lots of Delta sufferers are getting Omicron).

Could still be immune though.Some people just are.

[jdc]

Given that appx 12% of common cold infections are caused by a Coronavirus, there was a hypothesis that this would provide immunity to Covid-19.

I've no idea what the current thinking is on this.

I think that's been debunked. Even Covid doesn't give immunity against Covid. (Lots of Delta sufferers are getting Omicron).

Could still be immune though.Some people just are.

Nonspecific Defenses? https://www.ncbi.nlm.nih.gov/books/NBK8348/

Some nonspecific defenses exist independently of infection (e.g., genetic factors, anatomic barriers, nonspecific inhibitors in body fluids, and phagocytosis). Others (e.g., fever, inflammation, and interferon) are produced by the host in response to infection. All nonspecific defenses begin to act before the specific defense responses develop and can potentiate some of the established immune effector mechanisms.

[jdc]

Or just lucky?

I'm going with this as my guess.

[Woodchopper]

I seem to be in a similar situation.

My daughter came sown with a high fever on Friday, and tested positive. My wife was positive on Saturday and has a sore throat and a fever.

But my son and I have stayed negative and symptom free. I haven't even been taking any protective measures as my wife and daughter need looking after.

I got my third vaccination about ten days ago, so maybe I'm just very immune. My son never gets sick from anything, so maybe he is as well, just naturally.

[discovolante]

One of our friend's family all came down with it in October - well all except the dad initially, but he tested positive 6 days later. So be careful!

[Woodchopper]

One of our friend's family all came down with it in October - well all except the dad initially, but he tested positive 6 days later. So be careful!

Yes, it could arrive late. I'll keep testing myself every day.

[Herainestold]

One of our friend's family all came down with it in October - well all except the dad initially, but he tested positive 6 days later. So be careful!

Yes, it could arrive late. I'll keep testing myself every day.

As a household contact, how long are you required to isolate?

[Woodchopper]

One of our friend's family all came down with it in October - well all except the dad initially, but he tested positive 6 days later. So be careful!

Yes, it could arrive late. I'll keep testing myself every day.

As a household contact, how long are you required to isolate?

Where I am I'm not required to isloate if I test myself every day.

But I am isolating anyway.

[Herainestold]

Yes, it could arrive late. I'll keep testing myself every day.

As a household contact, how long are you required to isolate?

Where I am I'm not required to isloate if I test myself every day.

But I am isolating anyway.

I see. So you will isolate until your contacts are negative and have no symptoms and you remain negative with no symptoms?

[Woodchopper]

As a household contact, how long are you required to isolate?

Where I am I'm not required to isloate if I test myself every day.

But I am isolating anyway.

I see. So you will isolate until your contacts are negative and have no symptoms and you remain negative with no symptoms?

That's the plan.

I've been working from home and haven't done any social activities since Christmas. So there isn't much difference between isolating and normal life these days.

[Herainestold]

That's the plan.

I've been working from home and haven't done any social activities since Christmas. So there isn't much difference between isolating and normal life these days.

That is the future for most of us. At least those of us that can work and isolate at the same time.

[shpalman]

New results from the San Raffaele...

Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules

Apparently has something to do with this, whatever it is: https://en.wikipedia.org/wiki/Mannan-binding_lectin

[jdc]

New results from the San Raffaele...

Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules

Apparently has something to do with this, whatever it is: https://en.wikipedia.org/wiki/Mannan-binding_lectin

"host defense protein that acts as a broad-spectrum recognition molecule against a wide variety of infectious agents", apparently. Sounds like one of your Nonspecific Defenses...

Unlike T cells and B cells, which have high specificity, innate immune cells do not express specific antigen recognition receptors. Through the recognition and binding of some common molecules on the surface of pathogens, apoptotic host cells, and damaged senescent cells, pattern recognition receptors (PRRs) induce immunoprotective effects, such as anti-infection and antitumor effects, and participate in the initiation and effect process of specific immune response.

[warumich]

Oh, hope your family feel better soon chops. Mine are asymptomatic, so apart from sonnyboy celebrating not being at school by already being on his third run through the Mandalorian, nothing really exciting going on here.

Some development re gf though; last time I posted we she had just had a fairly clear positive on the ltf, though we were still waiting from the pcr test. Which came back negative. Next day, same thing, ltf shows positive (slightly fainter line, but still).

Not entirely sure what to make of it. She's isolating now, but do the clever people on here have any idea on whether false positives on ltf are more likely than false negatives on pcr? Or, like, what to make of it?

[shpalman]

Happened to my colleague: obvious symptoms, regularly positive when flowing laterally, PCR came back negative. He just tried to explain to them that they'd screwed something up, they were like "you're negative you can go out".

(It also happened to him that he got a positive result on a rapid test at the pharmacy but the pharmacist entered it as negative by habit and his Green Pass arrived from that and there wasn't a protocol for correcting that result...)

This was in December, he's fine now, sense of smell still a bit off though.

[jdc]

Oh, hope your family feel better soon chops. Mine are asymptomatic, so apart from sonnyboy celebrating not being at school by already being on his third run through the Mandalorian, nothing really exciting going on here.

Some development re gf though; last time I posted we she had just had a fairly clear positive on the ltf, though we were still waiting from the pcr test. Which came back negative. Next day, same thing, ltf shows positive (slightly fainter line, but still).

Not entirely sure what to make of it. She's isolating now, but do the clever people on here have any idea on whether false positives on ltf are more likely than false negatives on pcr? Or, like, what to make of it?

Here's some cherry-picked stats:

https://www.gov.uk/government/news/new- ... 2099.97%25.

New analysis published today shows lateral flow tests (LFD) to have a specificity of at least 99.9% when used to test in the community and could be as high as 99.97%.

https://www.bmj.com/content/372/bmj.n28 ... contagious.

Sensitivity of PCR testing in the real world (taking into consideration the likelihood of the virus getting onto the swab) is only of the order of 70%. It misses (gives false negative results) in about 30% of people who do actually have the virus, and who may be contagious.